دورية أكاديمية
Mild Electrical Stimulation with Heat Shock Reduces Visceral Adiposity and Improves Metabolic Abnormalities in Subjects with Metabolic Syndrome or Type 2 Diabetes: Randomized Crossover Trials
| العنوان: | Mild Electrical Stimulation with Heat Shock Reduces Visceral Adiposity and Improves Metabolic Abnormalities in Subjects with Metabolic Syndrome or Type 2 Diabetes: Randomized Crossover Trials |
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| المؤلفون: | Tatsuya Kondo, Kaoru Ono, Sayaka Kitano, Rina Matsuyama, Rieko Goto, Mary Ann Suico, Shuji Kawasaki, Motoyuki Igata, Junji Kawashima, Hiroyuki Motoshima, Takeshi Matsumura, Hirofumi Kai, Eiichi Araki |
| المصدر: | EBioMedicine, Vol 1, Iss 1, Pp 80-89 (2014) |
| بيانات النشر: | Elsevier, 2014. |
| سنة النشر: | 2014 |
| المجموعة: | LCC:Medicine LCC:Medicine (General) |
| مصطلحات موضوعية: | Metabolic syndrome, Type 2 diabetes, Heat shock response, Insulin resistance, Chronic inflammation, Medicine, Medicine (General), R5-920 |
| الوصف: | Background: The induction of heat shock protein (HSP) 72 by mild electrical stimulation with heat shock (MES + HS), which improves visceral adiposity and insulin resistance in mice, may be beneficial in treating metabolic syndrome (MS) or type 2 diabetes mellitus (T2DM). Methods: Using open-label crossover trials, 40 subjects with MS or T2DM were randomly assigned using computer-generated random numbers to 12 weeks of therapeutic MES + HS followed by 12 weeks of no treatment, or vice versa. During the intervention period, physical and biochemical markers were measured. Findings: Compared to no treatment, MES + HS treatment was associated with a significant decrease in visceral adiposity (−7.54 cm2 (−8.61%), 95% CI −8.55 to −6.53 (p = 0.037) in MS, −19.73 cm2 (−10.89%), 95% CI −20.97 to −18.49 (p = 0.003) in T2DM). Fasting plasma glucose levels were decreased by 3.74 mg/dL (−5.28%: 95% CI −4.37 to −3.09 mg/dL, p = 0.029) in MS and by 14.97 mg/dL (10.40%: 95% CI −15.79 to 14.15 mg/dL, p |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2352-3964 18954944 |
| Relation: | http://www.sciencedirect.com/science/article/pii/S2352396414000255; https://doaj.org/toc/2352-3964 |
| DOI: | 10.1016/j.ebiom.2014.11.001 |
| URL الوصول: | https://doaj.org/article/403bea18954944ce86134408c289eb7f |
| رقم الأكسشن: | edsdoj.403bea18954944ce86134408c289eb7f |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 23523964 18954944 |
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| DOI: | 10.1016/j.ebiom.2014.11.001 |