دورية أكاديمية
Analysis of anticancer potential of Kingiodendron pinnatum (DC.) Harms
| العنوان: | Analysis of anticancer potential of Kingiodendron pinnatum (DC.) Harms |
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| المؤلفون: | Chennattu M. Pareeth, Nair Meera, Prabha Silpa, Kannoor M. Thara, Achuthan C. Raghavamenon, Thekkekara D. Babu |
| المصدر: | Clinical Phytoscience, Vol 9, Iss 1, Pp 1-9 (2023) |
| بيانات النشر: | SpringerOpen, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Medicine LCC:Homeopathy |
| مصطلحات موضوعية: | Kingiodendron pinnatum, Saraca asoca, Asoka, Cytotoxicity, Anti-tumour, Reproductive cancer, Medicine, Homeopathy, RX1-681 |
| الوصف: | Abstract Background The plant Kingiodendron pinnatum (DC.) Harms, belonging to the family Fabaceae is endemic to the Western Ghats of India and is commonly used for various ailments, especially by the tribes. K. pinnatum is occasionally used as a substitute for Saraca asoca in Asokarishta, a well-known uterine tonic in Ayurveda. Recent studies revealed a pharmacological similarity between the plants. S. asoca is reported to have anti-cancer properties, but there are no reports on K. pinnatum except for antioxidant and antimicrobial activities. Therefore, the study is aimed to investigate the anticancer potential of the plant. Methods Cytotoxicity of methanolic bark extract of the plant was analysed on different cancer cell lines by 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT) assay. Dalton's lymphoma ascites (DLA) cell-induced solid and Ehrlich ascites carcinoma (EAC) cell-induced ascites tumour models in mice were used to study the antitumor potential. Phytochemical screening of the extract was also performed. Results The extract was found cytotoxic to DLA, EAC, HCT15, MDA-MB-231, T47D and PC3 with inhibitory concentration (IC50) values of 50.09, 74.74, 67.02, 119.22, 149.04 and 194.5 μg/mL, respectively. In the solid tumour model, a significant (P |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2199-1197 |
| Relation: | https://doaj.org/toc/2199-1197 |
| DOI: | 10.1186/s40816-023-00356-5 |
| URL الوصول: | https://doaj.org/article/409e22bc30a34c7099a7b8a87de8597f |
| رقم الأكسشن: | edsdoj.409e22bc30a34c7099a7b8a87de8597f |
| قاعدة البيانات: | Directory of Open Access Journals |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 21991197 |
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| DOI: | 10.1186/s40816-023-00356-5 |