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A Prognostic Model of Elderly Patients with Non-small Cell Lung Cancer Based on Geriatric Nutritional Risk Index

التفاصيل البيبلوغرافية
العنوان: A Prognostic Model of Elderly Patients with Non-small Cell Lung Cancer Based on Geriatric Nutritional Risk Index
المؤلفون: Xiaonan ZHANG, Yajun XIONG, Aiguo XU
المصدر: Chinese Journal of Lung Cancer, Vol 26, Iss 7, Pp 497-506 (2023)
بيانات النشر: Chinese Anti-Cancer Association; Chinese Antituberculosis Association, 2023.
سنة النشر: 2023
المجموعة: LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
مصطلحات موضوعية: geriatric nutritional risk index, elderly, lung neoplasms, overall survival rate, nutritional status, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
الوصف: Background and objective The relationship between nutritional status and prognosis of cancer patients has emerged as a hotspot for research. The aim of this study is to explore the application value of the geriatric nutritional risk index (GNRI) in assessing the prognosis of elderly patients with non-small cell lung cancer (NSCLC), and establish a Nomogram to predict the prognosis of elderly patients with NSCLC. Methods The data of patients with NSCLC aged ≥65 years who were initially treated in the First Affiliated Hospital of Zhengzhou University from January 2016 to December 2019 were retrospectively analyzed. To determine the optimal cut-off value for GNRI, receiver operating characteristic (ROC) curve was constructed, and the patients were divided into high and low GNRI groups. Kaplan-Meier curve and Log-rank test were used to compare overall survival (OS) of the two groups. Univariate and multivariate Cox regression was used to analyze the risk factors for poor prognosis in elderly patients with NSCLC. Nomogram predicting survival in elderly patients with NSCLC was constructed and validated by using R software. Results Statistically significant differences in age, gender, body mass index (BMI), histological type, albumin, treatment methods, neutrophil to lymphocyte ratio (NLR), prognostic nutritional index (PNI), systemic immune-inflammation index (SII) and cytokeratin 19 fragment (CYFRA21-1) were observed between the high and low GNRI groups (P3.3 ng/mL was an independent risk factor for the development of OS in patients with NSCLC, and GNRI>97.09 was a protective factor [hazard ratio (HR)=0.52, 95% confidence interval (CI): 0.34-0.79, P
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: Chinese
تدمد: 1009-3419
1999-6187
Relation: https://doaj.org/toc/1009-3419; https://doaj.org/toc/1999-6187
DOI: 10.3779/j.issn.1009-3419.2023.106.14
URL الوصول: https://doaj.org/article/40b1b33615a44f00be6fd2569dfc993c
رقم الأكسشن: edsdoj.40b1b33615a44f00be6fd2569dfc993c
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:10093419
19996187
DOI:10.3779/j.issn.1009-3419.2023.106.14