دورية أكاديمية
Diagnostic Evidence GAuge of Single cells (DEGAS): a flexible deep transfer learning framework for prioritizing cells in relation to disease
| العنوان: | Diagnostic Evidence GAuge of Single cells (DEGAS): a flexible deep transfer learning framework for prioritizing cells in relation to disease |
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| المؤلفون: | Travis S. Johnson, Christina Y. Yu, Zhi Huang, Siwen Xu, Tongxin Wang, Chuanpeng Dong, Wei Shao, Mohammad Abu Zaid, Xiaoqing Huang, Yijie Wang, Christopher Bartlett, Yan Zhang, Brian A. Walker, Yunlong Liu, Kun Huang, Jie Zhang |
| المصدر: | Genome Medicine, Vol 14, Iss 1, Pp 1-23 (2022) |
| بيانات النشر: | BMC, 2022. |
| سنة النشر: | 2022 |
| المجموعة: | LCC:Medicine LCC:Genetics |
| مصطلحات موضوعية: | Prognostic models, Survival, Cox proportional hazards, Single-cell RNA sequencing, scRNA-seq, Machine Learning, Medicine, Genetics, QH426-470 |
| الوصف: | Abstract We propose DEGAS (Diagnostic Evidence GAuge of Single cells), a novel deep transfer learning framework, to transfer disease information from patients to cells. We call such transferrable information “impressions,” which allow individual cells to be associated with disease attributes like diagnosis, prognosis, and response to therapy. Using simulated data and ten diverse single-cell and patient bulk tissue transcriptomic datasets from glioblastoma multiforme (GBM), Alzheimer’s disease (AD), and multiple myeloma (MM), we demonstrate the feasibility, flexibility, and broad applications of the DEGAS framework. DEGAS analysis on myeloma single-cell transcriptomics identified PHF19 high myeloma cells associated with progression. Availability: https://github.com/tsteelejohnson91/DEGAS . |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1756-994X |
| Relation: | https://doaj.org/toc/1756-994X |
| DOI: | 10.1186/s13073-022-01012-2 |
| URL الوصول: | https://doaj.org/article/a416f2c8e20d4df68f061235c38432e6 |
| رقم الأكسشن: | edsdoj.416f2c8e20d4df68f061235c38432e6 |
| قاعدة البيانات: | Directory of Open Access Journals |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 1756994X |
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| DOI: | 10.1186/s13073-022-01012-2 |