دورية أكاديمية
أعرض في EDS

Effects of the Cathepsin K Inhibitor ONO-5334 and Concomitant Use of ONO-5334 with Methotrexate on Collagen-Induced Arthritis in Cynomolgus Monkeys

التفاصيل البيبلوغرافية
العنوان: Effects of the Cathepsin K Inhibitor ONO-5334 and Concomitant Use of ONO-5334 with Methotrexate on Collagen-Induced Arthritis in Cynomolgus Monkeys
المؤلفون: Hiroyuki Yamada, Hiroshi Mori, Yasutomo Nakanishi, Satoshi Nishikawa, Yasuaki Hashimoto, Yasuo Ochi, Makoto Tanaka, Kazuhito Kawabata
المصدر: International Journal of Rheumatology, Vol 2019 (2019)
بيانات النشر: Hindawi Limited, 2019.
سنة النشر: 2019
المجموعة: LCC:Diseases of the musculoskeletal system
مصطلحات موضوعية: Diseases of the musculoskeletal system, RC925-935
الوصف: We examined whether the cathepsin K inhibitor, ONO-5334, administered alone or in combination with methotrexate (MTX), could ameliorate joint destruction evoked by collagen-induced arthritis (CIA) in female cynomolgus monkeys. CIA was induced by immunizing with bovine type II collagen. ONO-5334 (30 mg/kg/day) was orally administered once daily and MTX (10 mg/body/day) twice weekly for 9 weeks. X-ray (evaluation of joint destruction) and swelling (inflammatory) scores of proximal interphalangeal (PIP), distal interphalangeal (DIP), and metacarpophalangeal (MP) joints were evaluated. Urinary concentrations of C-terminal telopeptide of type I collagen (CTX-I) and type II collagen (CTX-II) were measured. Arthritis, accompanied by bone and cartilage destruction, was successfully induced in this collagen-induced arthritis monkey model. ONO-5334 showed no suppressive effect on joint swelling, while the joint swelling scores in the MTX and combination (ONO-5334 + MTX) groups were less than 50% compared with the control group. ONO-5334 decreased X-ray score by a mean of 64% (p
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1687-9260
1687-9279
Relation: https://doaj.org/toc/1687-9260; https://doaj.org/toc/1687-9279
DOI: 10.1155/2019/5710340
URL الوصول: https://doaj.org/article/4183d52815b84a93a1a5b90905b65ffa
رقم الأكسشن: edsdoj.4183d52815b84a93a1a5b90905b65ffa
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:16879260
16879279
DOI:10.1155/2019/5710340