دورية أكاديمية
Head and neck cancer management and cancer stem cells implication
| العنوان: | Head and neck cancer management and cancer stem cells implication |
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| المؤلفون: | Osama A. Elkashty, Ramy Ashry, Simon D. Tran |
| المصدر: | Saudi Dental Journal, Vol 31, Iss 4, Pp 395-416 (2019) |
| بيانات النشر: | Elsevier, 2019. |
| سنة النشر: | 2019 |
| المجموعة: | LCC:Medicine LCC:Dentistry |
| مصطلحات موضوعية: | Medicine, Dentistry, RK1-715 |
| الوصف: | Head and neck squamous cell carcinomas (HNSCCs) arise in the mucosal linings of the upper aerodigestive tract and are heterogeneous in nature. Risk factors for HNSCCs are smoking, excessive alcohol consumption, and the human papilloma virus. Conventional treatments are surgery, radiotherapy, chemotherapy, or a combined modality; however, no international standard mode of therapy exists. In contrast to the conventional model of clonal evolution in tumor development, there is a newly proposed theory based on the activity of cancer stem cells (CSCs) as the model for carcinogenesis. This “CSC hypothesis” may explain the high mortality rate, low response to treatments, and tendency to develop multiple tumors for HNSCC patients. We review current knowledge on HNSCC etiology and treatment, with a focus on CSCs, including their origins, identifications, and effects on therapeutic options. Keywords: Head and neck cancer, Carcinoma, Squamous cell, Cancer stem cells, Cancer treatment, Antineoplastic agents |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1013-9052 |
| Relation: | http://www.sciencedirect.com/science/article/pii/S1013905219305620; https://doaj.org/toc/1013-9052 |
| DOI: | 10.1016/j.sdentj.2019.05.010 |
| URL الوصول: | https://doaj.org/article/41a0b72edc0448c8b02e381cccc6468c |
| رقم الأكسشن: | edsdoj.41a0b72edc0448c8b02e381cccc6468c |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 10139052 |
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| DOI: | 10.1016/j.sdentj.2019.05.010 |