دورية أكاديمية
Features of epithelial-mesenchymal transition in ectopic endometrium in patients with extragenital endometriosis of various localizations. Observational study
| العنوان: | Features of epithelial-mesenchymal transition in ectopic endometrium in patients with extragenital endometriosis of various localizations. Observational study |
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| المؤلفون: | Eugeniu Cazacu, Eremei Zota, Mariam A. Vardanyan, Radu Niguleanu, Ruslan Pretula, Aleksandra V. Asaturova, Larisa S. Ezhova, Alina S. Badlaeva |
| المصدر: | Гинекология, Vol 26, Iss 2, Pp 159-164 (2024) |
| بيانات النشر: | IP Berlin A.V., 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Gynecology and obstetrics |
| مصطلحات موضوعية: | endometriosis, epithelial to mesenchymal transition process, extragenital endometriosis, Gynecology and obstetrics, RG1-991 |
| الوصف: | Background. Epithelial-mesenchymal transition (EMT) is a conserved mechanism in the process of morphogenesis and organogenesis. EMT provides cells with migratory and invasive properties, which is a necessary condition for the formation of endometrioid heterotopias. Aim. To confirm the presence of EMT features in different types of endometriosis. Materials and methods. During a period of five years (2012–2017) we analyzed 43 cases of extragenital endometriosis: appendix (3 case), colon (5 cases), ileum (1 case), abdominal scar endometriosis after caesarean section (24 cases), and inguinal hernia (10 cases). The material was processed according to histological and immunohistochemical technique using monoclonal E-cadherin and polyclonal Vimentin antibodies to assess local invasiveness. Results. In peritoneal endometriosis, the ratio of E-cadherin to Vimentin expression was 10.3, in the colon = 9.1, in the appendix 8.6, in the ileum 5.5, in the hernial sac 4.2. Thus, in diffuse infiltrative forms of endometriosis, the lesion phenotype is characterized by low expression of E-cadherin, while expression of Vimentin is at a high level (p0.05). Conclusion. The results of our study confirmed involvement of the epithelial-mesenchymal transition process in the pathogenesis of extragenital endometriosis lesions, on the one hand, and they certify its invasive potential in these localizations, on the other hand. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | Russian |
| تدمد: | 2079-5696 2079-5831 20795696 |
| Relation: | https://gynecology.orscience.ru/2079-5831/article/viewFile/627608/pdf; https://doaj.org/toc/2079-5696; https://doaj.org/toc/2079-5831 |
| DOI: | 10.26442/20795696.2024.2.202799 |
| URL الوصول: | https://doaj.org/article/41b1daeea00e4ee2b8d2336e5a8e24ed |
| رقم الأكسشن: | edsdoj.41b1daeea00e4ee2b8d2336e5a8e24ed |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 20795696 20795831 |
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| DOI: | 10.26442/20795696.2024.2.202799 |