دورية أكاديمية
Evaluation of 11 SARS-CoV-2 antibody tests by using samples from patients with defined IgG antibody titers
| العنوان: | Evaluation of 11 SARS-CoV-2 antibody tests by using samples from patients with defined IgG antibody titers |
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| المؤلفون: | Nina Lagerqvist, Kimia T. Maleki, Jenny Verner-Carlsson, Mikaela Olausson, Joakim Dillner, Julia Wigren Byström, Tor Monsen, Mattias Forsell, Jenny Eriksson, Gordana Bogdanovic, Sandra Muschiol, Joel Ljunggren, Johanna Repo, Torbjörn Kjerstadius, Shaman Muradrasoli, Mia Brytting, Åsa Szekely Björndal, Thomas Åkerlund, Charlotta Nilsson, Jonas Klingström |
| المصدر: | Scientific Reports, Vol 11, Iss 1, Pp 1-8 (2021) |
| بيانات النشر: | Nature Portfolio, 2021. |
| سنة النشر: | 2021 |
| المجموعة: | LCC:Medicine LCC:Science |
| مصطلحات موضوعية: | Medicine, Science |
| الوصف: | Abstract We evaluated the performance of 11 SARS-CoV-2 antibody tests using a reference set of heat-inactivated samples from 278 unexposed persons and 258 COVID-19 patients, some of whom contributed serial samples. The reference set included samples with a variation in SARS-CoV-2 IgG antibody titers, as determined by an in-house immunofluorescence assay (IFA). The five evaluated rapid diagnostic tests had a specificity of 99.0% and a sensitivity that ranged from 56.3 to 81.6% and decreased with low IFA IgG titers. The specificity was > 99% for five out of six platform-based tests, and when assessed using samples collected ≥ 22 days after symptom onset, two assays had a sensitivity of > 96%. These two assays also detected samples with low IFA titers more frequently than the other assays. In conclusion, the evaluated antibody tests showed a heterogeneity in their performances and only a few tests performed well with samples having low IFA IgG titers, an important aspect for diagnostics and epidemiological investigations. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2045-2322 |
| Relation: | https://doaj.org/toc/2045-2322 |
| DOI: | 10.1038/s41598-021-87289-6 |
| URL الوصول: | https://doaj.org/article/41c68a18600c4aeabe1e88c76d0accd3 |
| رقم الأكسشن: | edsdoj.41c68a18600c4aeabe1e88c76d0accd3 |
| قاعدة البيانات: | Directory of Open Access Journals |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 20452322 |
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| DOI: | 10.1038/s41598-021-87289-6 |