دورية أكاديمية
Possible neuropharmacological effects of Adenia trilobata (Roxb.) in the Swiss albino mice model
| العنوان: | Possible neuropharmacological effects of Adenia trilobata (Roxb.) in the Swiss albino mice model |
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| المؤلفون: | Md. Arfin Ibn Aziz, Niloy Barua, Abu Montakim Tareq, Najmul Alam, Ranak Jahan Prova, Miskatun Nur Mamun, Mohammed Aktar Sayeed, Md. Ashraf Uddin Chowdhury, Talha Bin Emran |
| المصدر: | Future Journal of Pharmaceutical Sciences, Vol 6, Iss 1, Pp 1-8 (2020) |
| بيانات النشر: | SpringerOpen, 2020. |
| سنة النشر: | 2020 |
| المجموعة: | LCC:Therapeutics. Pharmacology LCC:Pharmacy and materia medica |
| مصطلحات موضوعية: | Adenia trilobata, Neuropharmacological effects, Anxiolytic, Locomotor, Antidepressant, Therapeutics. Pharmacology, RM1-950, Pharmacy and materia medica, RS1-441 |
| الوصف: | Abstract Background Known colloquially as akandaphal in Bangladesh, Adenia trilobata has some traditional uses. Its leaves and stems are extracted with pure methanol (MEATL, MEATS) and fractioned by n-hexane (NFATL, NFATS). The in vivo anxiolytic activity was evaluated by elevated plus maze (EPM) testing and hole-board test (HBT), whilst the locomotor activity was examined using the open-field test (OFT) and hole-cross test (HCT) and the antidepressant activity was assessed with the forced swimming test (FST) and the tail suspension test (TST). Results Regarding the anxiolytic activity, the 400-mg/kg doses of MEATL, NFATL, MEATS and NFATS exhibited maximum percentages of entry into the open arm of 33.85%, 32.23%, 30.06% and 41.84%, respectively, compare with the diazepam (69.33%). During HBT, MEATL (400 mg/kg) and NFATL (400 mg/kg) demonstrated 51.67 ± 0.88 and 57.67 ± 3.18 instances of head-dipping relative to diazepam (64.33 ± 3.16), whilst the locomotor activity showed a dose-dependent reduction in square movements and number of hole crossings. During FST and TST, the NFATL (400 mg/kg) exhibited rates of 43.32% and 57.71% time spent immobile, whilst fluoxetine experienced rates of 54.79% and 55.74%. Conclusion Adenia trilobata could be a potential component for the treatment of neuropharmacological defects. Further study is required. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2314-7253 |
| Relation: | http://link.springer.com/article/10.1186/s43094-020-00102-5; https://doaj.org/toc/2314-7253 |
| DOI: | 10.1186/s43094-020-00102-5 |
| URL الوصول: | https://doaj.org/article/c421f0d013ae4346bfcac60b4a5d14a8 |
| رقم الأكسشن: | edsdoj.421f0d013ae4346bfcac60b4a5d14a8 |
| قاعدة البيانات: | Directory of Open Access Journals |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 23147253 |
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| DOI: | 10.1186/s43094-020-00102-5 |