دورية أكاديمية
Vascularized Tissue Organoids
| العنوان: | Vascularized Tissue Organoids |
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| المؤلفون: | Hannah A. Strobel, Sarah M. Moss, James B. Hoying |
| المصدر: | Bioengineering, Vol 10, Iss 2, p 124 (2023) |
| بيانات النشر: | MDPI AG, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Technology LCC:Biology (General) |
| مصطلحات موضوعية: | organoid, vascularization, spheroid, stem cell, microvessel, vessel, Technology, Biology (General), QH301-705.5 |
| الوصف: | Tissue organoids hold enormous potential as tools for a variety of applications, including disease modeling and drug screening. To effectively mimic the native tissue environment, it is critical to integrate a microvasculature with the parenchyma and stroma. In addition to providing a means to physiologically perfuse the organoids, the microvasculature also contributes to the cellular dynamics of the tissue model via the cells of the perivascular niche, thereby further modulating tissue function. In this review, we discuss current and developing strategies for vascularizing organoids, consider tissue-specific vascularization approaches, discuss the importance of perfusion, and provide perspectives on the state of the field. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2306-5354 |
| Relation: | https://www.mdpi.com/2306-5354/10/2/124; https://doaj.org/toc/2306-5354 |
| DOI: | 10.3390/bioengineering10020124 |
| URL الوصول: | https://doaj.org/article/4238e6dd6ec94e368d9256fd1a5e18ce |
| رقم الأكسشن: | edsdoj.4238e6dd6ec94e368d9256fd1a5e18ce |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 23065354 |
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| DOI: | 10.3390/bioengineering10020124 |