Structure-guided design of pure orthosteric inhibitors of αIIbβ3 that prevent thrombosis but preserve hemostasis

التفاصيل البيبلوغرافية
العنوان:	Structure-guided design of pure orthosteric inhibitors of αIIbβ3 that prevent thrombosis but preserve hemostasis
المؤلفون:	Brian D. Adair, José L. Alonso, Johannes van Agthoven, Vincent Hayes, Hyun Sook Ahn, I-Shing Yu, Shu-Wha Lin, Jian-Ping Xiong, Mortimer Poncz, M. Amin Arnaout
المصدر:	Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
بيانات النشر:	Nature Portfolio, 2020.
سنة النشر:	2020
المجموعة:	LCC:Science
مصطلحات موضوعية:	Science
الوصف:	Current inhibitors of platelet integrin αIIbβ3 cause excessive bleeding, which limited their clinical use in cardiac patients. Here the authors design pure orthosteric αIIbβ3 inhibitors that prevent platelet aggregation and thrombosis without causing bleeding in humanized mouse models of thrombosis
نوع الوثيقة:	article
وصف الملف:	electronic resource
اللغة:	English
تدمد:	2041-1723
Relation:	https://doaj.org/toc/2041-1723
DOI:	10.1038/s41467-019-13928-2
URL الوصول:	https://doaj.org/article/42565adb3ba2424890108c840e099336
رقم الأكسشن:	edsdoj.42565adb3ba2424890108c840e099336
قاعدة البيانات:	Directory of Open Access Journals

الوصف
تدمد:	20411723
DOI:	10.1038/s41467-019-13928-2