دورية أكاديمية
Sperm Mesoderm Specific Transcript Gene Methylation Status in Infertile Patients: A Systematic Review and Meta-Analysis
| العنوان: | Sperm Mesoderm Specific Transcript Gene Methylation Status in Infertile Patients: A Systematic Review and Meta-Analysis |
|---|---|
| المؤلفون: | Rossella Cannarella, Claudia Leanza, Andrea Crafa, Federica Barbagallo, Sandro La Vignera, Rosita Angela Condorelli, Aldo Eugenio Calogero |
| المصدر: | The World Journal of Men's Health, Vol 42, Iss 3, Pp 543-554 (2024) |
| بيانات النشر: | Korean Society for Sexual Medicine and Andrology, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Medicine LCC:Diseases of the genitourinary system. Urology |
| مصطلحات موضوعية: | epigenomics, infertility, methylation, oligospermia, Medicine, Diseases of the genitourinary system. Urology, RC870-923 |
| الوصف: | Purpose: The mesoderm specific transcription (MEST) gene is a paternally expressed imprinted gene that appears to play a role in embryo survival. The latest meta-analysis on MEST methylation pattern in spermatozoa of infertile patients found higher methylation in spermatozoa from infertile patients than fertile controls. To provide an updated and comprehensive systematic review and meta-analysis on the MEST gene methylation pattern in patients with abnormal sperm parameters compared to men with normal parameters. Materials and Methods: This meta-analysis was registered in PROSPERO (CRD42023397056) and performed following the MOOSE guidelines for Meta-analyses and Systematic Reviews of Observational Studies and the Preferred Reporting Items for Systematic Reviews and Meta-Analysis Protocols (PRISMA-P). Only original articles evaluating MEST gene methylation in spermatozoa from patients with infertility or abnormalities in one or more sperm parameters compared to fertile or normozoospermic men were included. Results: Of 354 abstracts evaluated for eligibility, only 6 studies were included in the quantitative synthesis, involving a total of 301 patients and 163 controls. Our analysis showed significantly higher levels of MEST gene methylation in patients compared with controls (standard mean difference [SMD] 2.150, 95% confidence interval [CI] 0.377, 3.922; p=0.017), although there was significant heterogeneity between studies (Q-value=239.90, p |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2287-4208 2287-4690 |
| Relation: | https://doaj.org/toc/2287-4208; https://doaj.org/toc/2287-4690 |
| DOI: | 10.5534/wjmh.230094 |
| URL الوصول: | https://doaj.org/article/425f26394422448fb781c524bde47b0e |
| رقم الأكسشن: | edsdoj.425f26394422448fb781c524bde47b0e |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 22874208 22874690 |
|---|---|
| DOI: | 10.5534/wjmh.230094 |