دورية أكاديمية
أعرض في EDS

Novel Prostate Cancer Biomarkers Derived from Autoantibody Signatures

التفاصيل البيبلوغرافية
العنوان: Novel Prostate Cancer Biomarkers Derived from Autoantibody Signatures
المؤلفون: Matthew Schipper, George Wang, Nick Giles, Jeanne Ohrnberger
المصدر: Translational Oncology, Vol 8, Iss 2, Pp 106-111 (2015)
بيانات النشر: Elsevier, 2015.
سنة النشر: 2015
المجموعة: LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
مصطلحات موضوعية: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
الوصف: BACKGROUND: Due to the low specificity of the prostate-specific antigen (PSA) assay and a high false positive rate, a large number of prostate cancer (PCA) biopsies are performed unnecessarily. Consequently, there is a need for new biomarkers that can identify PCA at any stage of progression while limiting the number of false positives. The use of autoantibody signature–developed biomarkers has proven to be an effective method to solve this problem. RESULTS: Using T7 phage–peptide detection, we identified a panel of eight biomarkers for PCA on a training set. The estimated receiver-operating characteristic (ROC) curve had an area under the ROC curve of 0.69 when applied to the validation set. Spearman correlations were high, within 0.7 to 0.9, indicating that the biomarkers have a degree of inter-relatedness. The identified biomarkers play a role in processes such as androgen response regulation and cellular structural integrity and are proteins that are thought to play a role in prostate tumorigenesis. CONCLUSIONS: Autoantibodies against PCA can be developed as biomarkers for detecting PCA. The scores from the algorithm developed here can be used to indicate a relative high or low risk of PCA, particularly for patients with intermediate (4.0 to 10 ng/ml) PSA levels. Since most commercially available assays test for PSA or have a PSA component, this novel approach has the potential to improve diagnosis of PCA using a biologic measure independent of PSA.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1936-5233
1944-7124
Relation: http://www.sciencedirect.com/science/article/pii/S1936523315000121; https://doaj.org/toc/1936-5233; https://doaj.org/toc/1944-7124
DOI: 10.1016/j.tranon.2015.02.003
URL الوصول: https://doaj.org/article/e42b44211f2744998455bb20aeb8d224
رقم الأكسشن: edsdoj.42b44211f2744998455bb20aeb8d224
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:19365233
19447124
DOI:10.1016/j.tranon.2015.02.003