دورية أكاديمية
Significance of tumor-associated macrophages in bladder cancer development
| العنوان: | Significance of tumor-associated macrophages in bladder cancer development |
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| المؤلفون: | V. N. Pavlov, M. F. Urmantsev, Yu. A. Korelov, M. R. Bakeev |
| المصدر: | Успехи молекулярной онкологии, Vol 9, Iss 3, Pp 8-14 (2022) |
| بيانات النشر: | ABV-press, 2022. |
| سنة النشر: | 2022 |
| المجموعة: | LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
| مصطلحات موضوعية: | макрофаги, ассоциированные с опухолью, мышечно-инвазивный рак мочевого пузыря, немышечно-инвазивный рак мочевого пузыря, микроокружение опухоли, канцерогенез, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282 |
| الوصف: | Bladder cancer is the 2nd most common urological oncological disease in the worlds. Tumors can be muscle invasive and non-muscle invasive. Recently, tumor microenvironment (TME) became a focus of investigation in malignant tumors of the bladder. According to the currently available data, TME is a specific environment crating optimal conditions for carcinogenesis in the neoplastic lesion. The main parts of TME are extracellular matrix and stroma including vasculature, stromal, and immune cells. Additionally, TME includes cytokines, chemokines, and other compounds activating signal pathways necessary for tumor cells. Tumor-associated macrophages (TAMs) are being extensively studied as representatives of TME in solid tumors of varying locations. These macrophages can be classified into 2 phenotypes: M1 (pro-inflammatory and antitumor) and M2 (anti-inflammatory and protumor). The phenotypes perform different roles, and M2 macrophages regulate the most important processes of oncogenesis (invasion, proliferation, neoangiogenesis, etc.). In the context of bladder cancer, M2 macrophages are the most significant as they are the most numerous TAMs in TME.Aim. To study the role of tumor-associated macrophages in development of bladder tumors, as well as prognostic value of these macrophages. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | Russian |
| تدمد: | 2313-805X 2413-3787 |
| Relation: | https://umo.abvpress.ru/jour/article/view/462; https://doaj.org/toc/2313-805X; https://doaj.org/toc/2413-3787 |
| DOI: | 10.17650/2313-805X-2022-9-3-8-14 |
| URL الوصول: | https://doaj.org/article/439559a23a524e85b44b70b9066e1066 |
| رقم الأكسشن: | edsdoj.439559a23a524e85b44b70b9066e1066 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 2313805X 24133787 |
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| DOI: | 10.17650/2313-805X-2022-9-3-8-14 |