دورية أكاديمية
Associations of plasma uromodulin and genetic variants with blood pressure responses to dietary salt interventions
| العنوان: | Associations of plasma uromodulin and genetic variants with blood pressure responses to dietary salt interventions |
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| المؤلفون: | Ming‐Fei Du, Shi Yao, Ting Zou, Jian‐Jun Mu, Xiao‐Yu Zhang, Gui‐Lin Hu, Chao Chu, Hao Jia, Yue‐Yuan Liao, Chen Chen, Dan Wang, Qiong Ma, Yu Yan, Ke‐Ke Wang, Yue Sun, Ze‐Jiaxin Niu, Rui‐Chen Yan, Xi Zhang, Hao‐Wei Zhou, Wei‐Hua Gao, Hao Li, Chun‐Hua Li, Ke Gao, Jie Zhang, Tie‐Lin Yang, Yang Wang |
| المصدر: | The Journal of Clinical Hypertension, Vol 23, Iss 10, Pp 1897-1906 (2021) |
| بيانات النشر: | Wiley, 2021. |
| سنة النشر: | 2021 |
| المجموعة: | LCC:Diseases of the circulatory (Cardiovascular) system |
| مصطلحات موضوعية: | gene polymorphism, hypertension, salt, salt sensitivity, uromodulin, Diseases of the circulatory (Cardiovascular) system, RC666-701 |
| الوصف: | Abstract Uromodulin, also named Tamm Horsfall protein, have been associated with renal function and sodium homeostasis regulation. The authors sought to examine the effects of salt intake on plasma and urinary uromodulin levels and the association of its genetic variants with salt sensitivity in Chinese adults. Eighty patients from our natural population cohort were maintained sequentially either on a usual diet for 3 days, a low‐salt diet (3.0 g) for 7 days, and a high‐salt diet (18.0 g) for an additional 7 days. In addition, the authors studied 514 patients of the Baoji Salt‐Sensitive Study, recruited from 124 families who received the same salt intake intervention, and investigated the association of genetic variations in uromodulin gene with salt sensitivity. Plasma uromodulin levels were significantly lower on a high‐salt diet than on a baseline diet (28.3 ± 4.5 vs. 54.9 ± 8.8 ng/ml). Daily urinary excretions of uromodulin were significantly decreased on a high‐salt diet than on a low‐salt diet (28.7 ± 6.7 vs. 157.2 ± 21.7 ng/ml). SNPs rs7193058 and rs4997081 were associated with the diastolic blood pressure (DBP), mean arterial pressure (MAP) responses to the high‐salt diet. In addition, several SNPs in the uromodulin gene were significantly associated with pulse pressure (PP) response to the low‐salt intervention. This study shows that dietary salt intake affects plasma and urinary uromodulin levels and that uromodulin may play a role in the pathophysiological process of salt sensitivity in the Chinese populations. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1751-7176 1524-6175 |
| Relation: | https://doaj.org/toc/1524-6175; https://doaj.org/toc/1751-7176 |
| DOI: | 10.1111/jch.14347 |
| URL الوصول: | https://doaj.org/article/43a3d83e7397430183097ab6c8e90002 |
| رقم الأكسشن: | edsdoj.43a3d83e7397430183097ab6c8e90002 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 17517176 15246175 |
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| DOI: | 10.1111/jch.14347 |