دورية أكاديمية

A Self‐Amplifying ROS‐Responsive Nanoplatform for Simultaneous Cuproptosis and Cancer Immunotherapy

التفاصيل البيبلوغرافية
العنوان: A Self‐Amplifying ROS‐Responsive Nanoplatform for Simultaneous Cuproptosis and Cancer Immunotherapy
المؤلفون: Hangyi Wu, Zhenhai Zhang, Yanni Cao, Yuhan Hu, Yi Li, Lanyi Zhang, Xinyi Cao, Haitong Wen, Youwen Zhang, Huixia Lv, Xin Jin
المصدر: Advanced Science, Vol 11, Iss 23, Pp n/a-n/a (2024)
بيانات النشر: Wiley, 2024.
سنة النشر: 2024
المجموعة: LCC:Science
مصطلحات موضوعية: cinnamaldehyde, cuproptosis, elesclomol, immunogenic cell death, ROS‐responsive, self‐amplifying nanoplatform, Science
الوصف: Abstract Cuproptosis is an emerging cell death pathway that depends on the intracellular Cu ions. Elesclomol (ES) as an efficient Cu ionophore can specifically transport Cu into mitochondria and trigger cuproptosis. However, ES can be rapidly removed and metabolized during intravenous administration, leading to a short half‐life and limited tumor accumulation, which hampers its clinical application. Here, the study develops a reactive oxygen species (ROS)‐responsive polymer (PCP) based on cinnamaldehyde (CA) and polyethylene glycol (PEG) to encapsulate ES‐Cu compound (EC), forming ECPCP. ECPCP significantly prolongs the systemic circulation of EC and enhances its tumor accumulation. After cellular internalization, the PCP coating stimulatingly dissociates exposing to the high‐level ROS, and releases ES and Cu, thereby triggering cell death via cuproptosis. Meanwhile, Cu2+‐stimulated Fenton‐like reaction together with CA‐stimulated ROS production simultaneously breaks the redox homeostasis, which compensates for the insufficient oxidative stress treated with ES alone, in turn inducing immunogenic cell death of tumor cells, achieving simultaneous cuproptosis and immunotherapy. Furthermore, the excessive ROS accelerates the stimuli‐dissociation of ECPCP, forming a positive feedback therapy loop against tumor self‐alleviation. Therefore, ECPCP as a nanoplatform for cuproptosis and immunotherapy improves the dual antitumor mechanism of ES and provides a potential optimization for ES clinical application.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2198-3844
20240104
Relation: https://doaj.org/toc/2198-3844
DOI: 10.1002/advs.202401047
URL الوصول: https://doaj.org/article/43aada3c6bf348c986179f85bc265b52
رقم الأكسشن: edsdoj.43aada3c6bf348c986179f85bc265b52
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:21983844
20240104
DOI:10.1002/advs.202401047