دورية أكاديمية
A Self‐Amplifying ROS‐Responsive Nanoplatform for Simultaneous Cuproptosis and Cancer Immunotherapy
العنوان: | A Self‐Amplifying ROS‐Responsive Nanoplatform for Simultaneous Cuproptosis and Cancer Immunotherapy |
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المؤلفون: | Hangyi Wu, Zhenhai Zhang, Yanni Cao, Yuhan Hu, Yi Li, Lanyi Zhang, Xinyi Cao, Haitong Wen, Youwen Zhang, Huixia Lv, Xin Jin |
المصدر: | Advanced Science, Vol 11, Iss 23, Pp n/a-n/a (2024) |
بيانات النشر: | Wiley, 2024. |
سنة النشر: | 2024 |
المجموعة: | LCC:Science |
مصطلحات موضوعية: | cinnamaldehyde, cuproptosis, elesclomol, immunogenic cell death, ROS‐responsive, self‐amplifying nanoplatform, Science |
الوصف: | Abstract Cuproptosis is an emerging cell death pathway that depends on the intracellular Cu ions. Elesclomol (ES) as an efficient Cu ionophore can specifically transport Cu into mitochondria and trigger cuproptosis. However, ES can be rapidly removed and metabolized during intravenous administration, leading to a short half‐life and limited tumor accumulation, which hampers its clinical application. Here, the study develops a reactive oxygen species (ROS)‐responsive polymer (PCP) based on cinnamaldehyde (CA) and polyethylene glycol (PEG) to encapsulate ES‐Cu compound (EC), forming ECPCP. ECPCP significantly prolongs the systemic circulation of EC and enhances its tumor accumulation. After cellular internalization, the PCP coating stimulatingly dissociates exposing to the high‐level ROS, and releases ES and Cu, thereby triggering cell death via cuproptosis. Meanwhile, Cu2+‐stimulated Fenton‐like reaction together with CA‐stimulated ROS production simultaneously breaks the redox homeostasis, which compensates for the insufficient oxidative stress treated with ES alone, in turn inducing immunogenic cell death of tumor cells, achieving simultaneous cuproptosis and immunotherapy. Furthermore, the excessive ROS accelerates the stimuli‐dissociation of ECPCP, forming a positive feedback therapy loop against tumor self‐alleviation. Therefore, ECPCP as a nanoplatform for cuproptosis and immunotherapy improves the dual antitumor mechanism of ES and provides a potential optimization for ES clinical application. |
نوع الوثيقة: | article |
وصف الملف: | electronic resource |
اللغة: | English |
تدمد: | 2198-3844 20240104 |
Relation: | https://doaj.org/toc/2198-3844 |
DOI: | 10.1002/advs.202401047 |
URL الوصول: | https://doaj.org/article/43aada3c6bf348c986179f85bc265b52 |
رقم الأكسشن: | edsdoj.43aada3c6bf348c986179f85bc265b52 |
قاعدة البيانات: | Directory of Open Access Journals |
تدمد: | 21983844 20240104 |
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DOI: | 10.1002/advs.202401047 |