دورية أكاديمية
Genetic polymorphism of Plasmodium falciparum circumsporozoite protein on Bioko Island, Equatorial Guinea and global comparative analysis
| العنوان: | Genetic polymorphism of Plasmodium falciparum circumsporozoite protein on Bioko Island, Equatorial Guinea and global comparative analysis |
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| المؤلفون: | Hui-Ying Huang, Xue-Yan Liang, Li-Yun Lin, Jiang-Tao Chen, Carlos Salas Ehapo, Urbano Monsuy Eyi, Jian Li, Ting-Ting Jiang, Yu-Zhong Zheng, Guang-Cai Zha, Dong-De Xie, Jin-Quan He, Wei-Zhong Chen, Xiang-Zhi Liu, Huan-Tong Mo, Xin-Yao Chen, Min Lin |
| المصدر: | Malaria Journal, Vol 19, Iss 1, Pp 1-13 (2020) |
| بيانات النشر: | BMC, 2020. |
| سنة النشر: | 2020 |
| المجموعة: | LCC:Arctic medicine. Tropical medicine LCC:Infectious and parasitic diseases |
| مصطلحات موضوعية: | Malaria, Plasmodium falciparum, Circumsporozoite protein, Genetic polymorphism, Bioko Island, Arctic medicine. Tropical medicine, RC955-962, Infectious and parasitic diseases, RC109-216 |
| الوصف: | Abstract Background Plasmodium falciparum circumsporozoite protein (PfCSP) is a potential malaria vaccine candidate, but various polymorphisms of the pfcsp gene among global P. falciparum population become the major barrier to the effectiveness of vaccines. This study aimed to investigate the genetic polymorphisms and natural selection of pfcsp in Bioko and the comparison among global P. falciparum population. Methods From January 2011 to December 2018, 148 blood samples were collected from P. falciparum infected Bioko patients and 96 monoclonal sequences of them were successfully acquired and analysed with 2200 global pfcsp sequences mined from MalariaGEN Pf3k Database and NCBI. Results In Bioko, the N-terminus of pfcsp showed limited genetic variations and the numbers of repetitive sequences (NANP/NVDP) were mainly found as 40 (35%) and 41 (34%) in central region. Most polymorphic characters were found in Th2R/Th3R region, where natural selection (p > 0.05) and recombination occurred. The overall pattern of Bioko pfcsp gene had no obvious deviation from African mainland pfcsp (Fst = 0.00878, p |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1475-2875 |
| Relation: | http://link.springer.com/article/10.1186/s12936-020-03315-4; https://doaj.org/toc/1475-2875 |
| DOI: | 10.1186/s12936-020-03315-4 |
| URL الوصول: | https://doaj.org/article/44762701b1364a9283fb854a2e5dd8d7 |
| رقم الأكسشن: | edsdoj.44762701b1364a9283fb854a2e5dd8d7 |
| قاعدة البيانات: | Directory of Open Access Journals |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 14752875 |
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| DOI: | 10.1186/s12936-020-03315-4 |