دورية أكاديمية
EARLY-ONSET COLORECTAL CANCER: AN ELEVEN-YEAR ANALYSIS OF CLINICOPATHOLOGICAL CHARACTERISTICS AT A TERTIARY HEALTHCARE CENTER
| العنوان: | EARLY-ONSET COLORECTAL CANCER: AN ELEVEN-YEAR ANALYSIS OF CLINICOPATHOLOGICAL CHARACTERISTICS AT A TERTIARY HEALTHCARE CENTER |
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| المؤلفون: | Jean Félix PIÑERÚA-GONSÁLVEZ, Rosanna del Carmen ZAMBRANO-INFANTINO, María Antonella RIZZO-RODRÍGUEZ, Aurelio DUEÑAS-DIEZ, Luis FERNÁNDEZ-SALAZAR |
| المصدر: | Arquivos de Gastroenterologia, Vol 60, Iss 3, Pp 315-321 (2023) |
| بيانات النشر: | Instituto Brasileiro de Estudos e Pesquisas de Gastroenterologia (IBEPEGE), 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Diseases of the digestive system. Gastroenterology |
| مصطلحات موضوعية: | Colorectal cancer, early-onset, young age, clinicopathological features, Diseases of the digestive system. Gastroenterology, RC799-869 |
| الوصف: | ABSTRACT Background: Early-onset colorectal cancer (EO-CRC) incidence has increased significantly worldwide in recent years, and these individuals frequently have advanced disease at the time of diagnosis. This study examines the clinicopathological characteristics of EO-CRC cases diagnosed at an academic healthcare center in Spain. Methods: A retrospective record review study of patients diagnosed with EO-CRC from 2010 to 2021 was performed. Clinical and pathological data were collected. Results: A total of 101 patients were included. The majority of cases (75.3%) were diagnosed in the age group between 40 and 49 years, specifically within the subgroup of 46-49 years. A family history of colorectal cancer was found in 23% of patients. Left-sided tumors were more common (43.6%), and most patients were diagnosed at advanced stages (34.7% at stage III and 32.7% at stage IV). The majority of patients (94.1%) were symptomatic, with rectal bleeding being the most prevalent clinical presentation. The most frequent histological type was moderately differentiated adenocarcinoma (44.6%). KRAS mutant tumors were found in 18.8% and BRAF mutant tumors in 11.9%. 67.3% had microsatellite stability. Tumor recurrence occurred in 24.8% of the patients, while 27.7% of the patients died. Conclusion: From 2010 to 2021, EO-CRC accounted for 3% of all colorectal cancer cases. To improve early diagnosis and treatment, physicians should maintain a high suspicion of red flag symptoms in young patients. To decrease EO-CRC morbidity and mortality, starting diagnostic screening tests at age 45 should be considered. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1678-4219 0004-2803 |
| Relation: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-28032023000300315&lng=en&tlng=en; http://www.scielo.br/pdf/ag/v60n3/1678-4219-ag-60-03-315.pdf; https://doaj.org/toc/1678-4219 |
| DOI: | 10.1590/s0004-2803.230302023-23 |
| URL الوصول: | https://doaj.org/article/449ab42805fa4e2baead6565b065f55b |
| رقم الأكسشن: | edsdoj.449ab42805fa4e2baead6565b065f55b |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 16784219 00042803 |
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| DOI: | 10.1590/s0004-2803.230302023-23 |