Discovery of a dual Ras and ARF6 inhibitor from a GPCR endocytosis screen

التفاصيل البيبلوغرافية
العنوان:	Discovery of a dual Ras and ARF6 inhibitor from a GPCR endocytosis screen
المؤلفون:	Jenna Giubilaro, Doris A. Schuetz, Tomasz M. Stepniewski, Yoon Namkung, Etienne Khoury, Mónica Lara-Márquez, Shirley Campbell, Alexandre Beautrait, Sylvain Armando, Olivier Radresa, Jean Duchaine, Nathalie Lamarche-Vane, Audrey Claing, Jana Selent, Michel Bouvier, Anne Marinier, Stéphane A. Laporte
المصدر:	Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
بيانات النشر:	Nature Portfolio, 2021.
سنة النشر:	2021
المجموعة:	LCC:Science
مصطلحات موضوعية:	Science
الوصف:	While Ras is a promising target for cancer therapy, development of inhibitors targeting Ras signaling has proven challenging. Here, the authors report the discovery of Rasarfin, a small molecule from a phenotypic screen on G protein-coupled receptor (GPCR) endocytosis that acts as a dual Ras and ARF6 inhibitor.
نوع الوثيقة:	article
وصف الملف:	electronic resource
اللغة:	English
تدمد:	2041-1723
Relation:	https://doaj.org/toc/2041-1723
DOI:	10.1038/s41467-021-24968-y
URL الوصول:	https://doaj.org/article/ec44bf6899064e34b2049b207a9e9931
رقم الأكسشن:	edsdoj.44bf6899064e34b2049b207a9e9931
قاعدة البيانات:	Directory of Open Access Journals

الوصف
تدمد:	20411723
DOI:	10.1038/s41467-021-24968-y