التفاصيل البيبلوغرافية
العنوان:
A Serum Circulating miRNA Signature for Short-Term Risk of Progression to Active Tuberculosis Among Household Contacts
المؤلفون:
Fergal J. Duffy , Ethan Thompson , Katrina Downing , Sara Suliman , Harriet Mayanja-Kizza , W. Henry Boom , Bonnie Thiel , January Weiner III , Stefan H. E. Kaufmann , Drew Dover , David L. Tabb , Hazel M. Dockrell , Tom H. M. Ottenhoff , Gerard Tromp , Thomas J. Scriba , Daniel E. Zak , Gerhard Walzl , the GC6-74 Consortium , S. H. E. Kaufmann , S. K. Parida , R. Golinski , J. Maertzdorf , J. Weiner , M. Jacobson , G. McEwen , G. Walzl , G. Black , G. van der Spuy , K. Stanley , M. Kriel , N. Du Plessis , N. Nene , A. Loxton , N. N. Chegou , S. Suliman , T. Scriba , H. Mahomed , M. Erasmus , O. Xasa , A. Veldsman , J. Hughes , K. Downing , A. Penn-Nicholson , H. Mulenga , B. Abel , M. Bowmaker , B. Kagina , W. Kwong C , W. Hanekom , T. H. M. Ottenhoff , M. R. Klein , M. C. Haks , K. L. Franken , A. Geluk , K. E. van Meijgaarden , S. A. Joosten , D. van Baarle , F. Miedema , W. H. Boom , B. Thiel , J. Sadoff , D. Sizemore , S. Ramachandran , L. Barker , M. Brennan , F. Weichold , S. Muller , L. Geiter , G. Schoolnik , G. Dolganov , T. Van , H. Mayanja-Kizza , M. Joloba , S. Zalwango , M. Nsereko , B. Okwera , H. Kisingo , H. Dockrell , S. Smith , P. Gorak-Stolinska , Y.-G. Hur , M. Lalor , J.-S. Lee , A. C. Crampin , N. French , B. Ngwira , A. B. Smith , K. Watkins , L. Ambrose , F. Simukonda , H. Mvula , F. Chilongo , J. Saul , K. Branson , D. Kassa , A. Abebe , T. Mesele , B. Tegbaru , R. Howe , A. Mihret , A. Aseffa , Y. Bekele , R. Iwnetu , M. Tafesse , L. Yamuah , M. Ota , J. Sutherland , P. Hill , R. Adegbola , T. Corrah , M. Antonio , T. Togun , I. Adetifa , S. Donkor , P. Andersen , I. Rosenkrands , M. Doherty , K. Weldingh
المصدر:
Frontiers in Immunology, Vol 9 (2018)
بيانات النشر:
Frontiers Media S.A., 2018.
سنة النشر:
2018
المجموعة:
LCC:Immunologic diseases. Allergy
مصطلحات موضوعية:
tuberculosis , microRNA , household contact , biomarker , correlate of risk , machine learning , Immunologic diseases. Allergy , RC581-607
الوصف:
Biomarkers that predict who among recently Mycobacterium tuberculosis (MTB)-exposed individuals will progress to active tuberculosis are urgently needed. Intracellular microRNAs (miRNAs) regulate the host response to MTB and circulating miRNAs (c-miRNAs) have been developed as biomarkers for other diseases. We performed machine-learning analysis of c-miRNA measurements in the serum of adult household contacts (HHCs) of TB index cases from South Africa and Uganda and developed a c-miRNA-based signature of risk for progression to active TB. This c-miRNA-based signature significantly discriminated HHCs within 6 months of progression to active disease from HHCs that remained healthy in an independent test set [ROC area under the ROC curve (AUC) 0.74, progressors
نوع الوثيقة:
article
وصف الملف:
electronic resource
اللغة:
English
تدمد:
1664-3224
Relation:
http://journal.frontiersin.org/article/10.3389/fimmu.2018.00661/full ; https://doaj.org/toc/1664-3224
DOI:
10.3389/fimmu.2018.00661
URL الوصول:
https://doaj.org/article/a450c97d56b9481c89cbc4507d35a4ef
رقم الأكسشن:
edsdoj.450c97d56b9481c89cbc4507d35a4ef
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