دورية أكاديمية
PABPN1 regulates mRNA alternative polyadenylation to inhibit bladder cancer progression
| العنوان: | PABPN1 regulates mRNA alternative polyadenylation to inhibit bladder cancer progression |
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| المؤلفون: | Liang Chen, Wei Dong, Menghao Zhou, Chenlu Yang, Ming Xiong, Gallina Kazobinka, Zhaohui Chen, Yifei Xing, Teng Hou |
| المصدر: | Cell & Bioscience, Vol 13, Iss 1, Pp 1-15 (2023) |
| بيانات النشر: | BMC, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Biotechnology LCC:Biology (General) LCC:Biochemistry |
| مصطلحات موضوعية: | PABPN1, Bladder cancer, Alternative polyadenylation, Wnt signaling, Cell cycle, Lipid biosynthesis, Biotechnology, TP248.13-248.65, Biology (General), QH301-705.5, Biochemistry, QD415-436 |
| الوصف: | Abstract Background About 10–20% of patients with bladder cancer (BC) progress to muscle-invasive diseases, of which the underlying key molecular events have yet to be addressed. Results Here, we identified poly(A) binding protein nuclear 1 (PABPN1), a general factor of alternative polyadenylation (APA), was downregulated in BC. Overexpression and knockdown of PABPN1 significantly decreased and increased BC aggressiveness, respectively. Mechanistically, we provide evidence that the preference of PABPN1-bound polyadenylation signals (PASs) depends on the relative location between canonical and non-canonical PASs. PABPN1 shapes inputs converging on Wnt signaling, cell cycle, and lipid biosynthesis. Conclusions Together, these findings provide insights into how PABPN1-mediated APA regulation contributes to BC progression, and suggest that pharmacological targeting PABPN1 might have therapeutic potential in patients with BC. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2045-3701 |
| Relation: | https://doaj.org/toc/2045-3701 |
| DOI: | 10.1186/s13578-023-00997-6 |
| URL الوصول: | https://doaj.org/article/e451703b5a6544efaf9c46fa8a085728 |
| رقم الأكسشن: | edsdoj.451703b5a6544efaf9c46fa8a085728 |
| قاعدة البيانات: | Directory of Open Access Journals |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 20453701 |
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| DOI: | 10.1186/s13578-023-00997-6 |