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Increased risk of malignancy in patients with Takayasu’s arteritis: a population-based cohort study in Korea

التفاصيل البيبلوغرافية
العنوان: Increased risk of malignancy in patients with Takayasu’s arteritis: a population-based cohort study in Korea
المؤلفون: Seulkee Lee, Seonyoung Kang, Yeonghee Eun, Hyungjin Kim, Jaejoon Lee, Eun-Mi Koh, Hoon-Suk Cha
المصدر: Scientific Reports, Vol 12, Iss 1, Pp 1-9 (2022)
بيانات النشر: Nature Portfolio, 2022.
سنة النشر: 2022
المجموعة: LCC:Medicine
LCC:Science
مصطلحات موضوعية: Medicine, Science
الوصف: Abstract This study aimed to evaluate the relative risk of malignancy in patients with Takayasu’s arteritis compared to that in the general population. This retrospective nationwide cohort study used data from the Korean Health Insurance Review and Assessment Service database. All newly diagnosed patients with Takayasu’s arteritis were identified between January 2009 and December 2019. They were observed until the diagnosis of malignancy, death, or end of the observational period, December 2020. The standardized incidence ratios (SIRs) of the overall and site-specific malignancies were estimated and compared with the incidence of cancer in the general population retrieved from the National Cancer Registry. We identified 1449 newly diagnosed patients with Takayasu’s arteritis during the observational period (9196 person-years). A total of 74, 66, and 8 patients had overall, solid, and hematologic malignancies, respectively. The risks of overall [SIR, 1.62; 95% confidence interval (CI) 1.27–2.03], solid (SIR, 1.51; 95% CI 1.17–1.92), and hematologic (SIR, 4.05; 95% CI 1.75–7.98) malignancies were increased compared to those in the general population. In solid malignancies, breast (SIR, 2.07; 95% CI 1.16–3.42) and ovarian (SIR, 4.45; 95% CI 1.21–11.39) cancers had an increased risk. In hematologic malignancies, the risk of myelodysplasia increased (SIR, 18.02; 95% CI 3.72–52.66). Immunosuppressive agent use was not associated with malignancy. There was no specific period when cancer more frequently occurred. An increased risk of malignancy was observed in patients with Takayasu’s arteritis compared to that in the general population in this large-scale nationwide population study of Korean health insurance data.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2045-2322
Relation: https://doaj.org/toc/2045-2322
DOI: 10.1038/s41598-022-24324-0
URL الوصول: https://doaj.org/article/45839eb468974efdaf97e21584c8d25b
رقم الأكسشن: edsdoj.45839eb468974efdaf97e21584c8d25b
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:20452322
DOI:10.1038/s41598-022-24324-0