دورية أكاديمية
Prognostic value of CAIX expression in oral squamous cell carcinoma: a systematic review and meta-analysis
| العنوان: | Prognostic value of CAIX expression in oral squamous cell carcinoma: a systematic review and meta-analysis |
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| المؤلفون: | Alejandro I. Lorenzo-Pouso, Mercedes Gallas-Torreira, Mario Pérez-Sayáns, Cintia M. Chamorro-Petronacci, Oscar Alvarez-Calderon, Bahi Takkouche, Claudiu T. Supuran, Abel García-García |
| المصدر: | Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 35, Iss 1, Pp 1258-1266 (2020) |
| بيانات النشر: | Taylor & Francis Group, 2020. |
| سنة النشر: | 2020 |
| المجموعة: | LCC:Therapeutics. Pharmacology |
| مصطلحات موضوعية: | mouth neoplasm, carbonic anhydrase, meta-analysis, prognosis, hypoxia, Therapeutics. Pharmacology, RM1-950 |
| الوصف: | Carbonic anhydrase IX (CAIX) is a hypoxia-related protein considered as a predictor for oral squamous cell carcinoma (OSCC) biological behaviour. Nevertheless, this prognostic value is still yet to be validated. We aim to quantify prognostic significance of CAIX overexpression in OSCC by meta-analysis. We performed searches in MEDLINE, EMBASE, SCOPUS, WOS, WHO’S databases, CPCI, and OATD from inception to August 2019. Overall survival (OS), disease-free survival (DFS), locoregional control (LC), and disease-specific survival (DSS) were considered as outcomes of interest. Overall 18 studies were included. CAIX overexpression was associated with worse OS (hazard ratio [HR] = 1.45 95% confidence interval [CI] 1.17–1.80) and DFS (HR = 1.98 95% CI 1.18–3.32). To the contrary, it was neither associated with LC (HR = 1.01 95% CI 0.50–2.02) nor with DSS (HR = 1.35 95% CI 0.78–2.33). Heterogeneity was negligible in all analyses except for DSS. Small studies effect was not significant for OS and DFS. This study shows that immunohistochemical CAIX assessment is a useful OSCC prognostic biomarker. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1475-6366 1475-6374 14756366 |
| Relation: | https://doaj.org/toc/1475-6366; https://doaj.org/toc/1475-6374 |
| DOI: | 10.1080/14756366.2020.1772250 |
| URL الوصول: | https://doaj.org/article/4596948d64114b9cabc8690e27eb751d |
| رقم الأكسشن: | edsdoj.4596948d64114b9cabc8690e27eb751d |
| قاعدة البيانات: | Directory of Open Access Journals |
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Full Text Finder | تدمد: | 14756366 14756374 |
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| DOI: | 10.1080/14756366.2020.1772250 |