دورية أكاديمية
Dynamic Brain Activity Following Auricular Point Acupressure in Chemotherapy-Induced Neuropathy: A Pilot Longitudinal Functional Magnetic Resonance Imaging Study
| العنوان: | Dynamic Brain Activity Following Auricular Point Acupressure in Chemotherapy-Induced Neuropathy: A Pilot Longitudinal Functional Magnetic Resonance Imaging Study |
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| المؤلفون: | Chao Hsing Yeh PhD, MSN, RN, Keenan Caswell BSc, BA, Sonaali Pandiri BA, Haris Sair MD, Nada Lukkahatai PhD, MSN, RN, Claudia M Campbell PhD, Vered Stearns MD, Barbara Van de Castle DNP, ACNS, OCN, RN-BC, Nancy Perrin PhD, MA, Thomas J Smith MD, Leorey N Saligan PhD, RN, CRNP |
| المصدر: | Global Advances in Health and Medicine, Vol 9 (2020) |
| بيانات النشر: | SAGE Publishing, 2020. |
| سنة النشر: | 2020 |
| المجموعة: | LCC:Medicine (General) LCC:Public aspects of medicine |
| مصطلحات موضوعية: | Medicine (General), R5-920, Public aspects of medicine, RA1-1270 |
| الوصف: | Background The objective of this study was to investigate the dynamic brain activity following auricular point acupressure (APA) in chemotherapy-induced neuropathy (CIN). Methods Participants received 4 weeks of APA in an open-pilot trial with repeated observation. Along with the clinical self-reported CIN outcomes, objective outcomes were measured over the course of the treatment by physiological changes in pain sensory thresholds from quantitative sensory testing (QST) and repeated functional magnetic resonance imaging scans. Results After 4 weeks of APA, participants had reported clinically significant improvements (ie, ≥30%) in a reduction of CIN symptoms (including pain, numbness, tingling, and stiffness) in lower extremity stiffness (32%), reduced foot sensitivity (13%), and higher pain threshold (13%). Across the 11 intrinsic brain networks examined, there was a trend toward significance of the connectivity of the basal ganglia network (BGN) to the salience network (SAL), which was decreased pre-APA versus immediate-APA (effect size [ES] = 1.04, P = .07). The BGN also demonstrated decreased connectivity with the language network pre-APA versus delayed imaging post-APA (ES = −0.92, P = .07). Furthermore, there was increased executive control network (ECN) and SAL within-network connectivity comparing pre-APA to delayed imaging post-APA, trending toward significance (ES = 0.41, P = .09 and ES = 0.17, P = .09, respectively). Conclusion The changes in connectivity and activity within or between the ECN, SAL, and BGN from pre- to post-APA suggest ongoing alterations in brain functional connectivity following APA, particularly in the insula, anterior cingulate, and dorsolateral prefrontal cortices, which play significant roles in pain, memory, and cognitive function. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2164-9561 21649561 |
| Relation: | https://doaj.org/toc/2164-9561 |
| DOI: | 10.1177/2164956120906092 |
| URL الوصول: | https://doaj.org/article/45a6585b8ac7444a83a949ed230c898f |
| رقم الأكسشن: | edsdoj.45a6585b8ac7444a83a949ed230c898f |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 21649561 |
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| DOI: | 10.1177/2164956120906092 |