دورية أكاديمية

Geometric construction of viral genome space and its applications

التفاصيل البيبلوغرافية
العنوان: Geometric construction of viral genome space and its applications
المؤلفون: Nan Sun, Shaojun Pei, Lily He, Changchuan Yin, Rong Lucy He, Stephen S.-T. Yau
المصدر: Computational and Structural Biotechnology Journal, Vol 19, Iss , Pp 4226-4234 (2021)
بيانات النشر: Elsevier, 2021.
سنة النشر: 2021
المجموعة: LCC:Biotechnology
مصطلحات موضوعية: Genome space, Geometry, Natural metric, Virus, Biotechnology, TP248.13-248.65
الوصف: Understanding the relationships between genomic sequences is essential to the classification and characterization of living beings. The classes and characteristics of an organism can be identified in the corresponding genome space. In the genome space, the natural metric is important to describe the distribution of genomes. Therefore, the similarity of two biological sequences can be measured. Here, we report that all of the viral genomes are in 32-dimensional Euclidean space, in which the natural metric is the weighted summation of Euclidean distance of k-mer natural vectors. The classification of viral genomes in the constructed genome space further proves the convex hull principle of taxonomy, which states that convex hulls of different families are mutually disjoint. This study provides a novel geometric perspective to describe the genome sequences.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2001-0370
Relation: http://www.sciencedirect.com/science/article/pii/S2001037021003184; https://doaj.org/toc/2001-0370
DOI: 10.1016/j.csbj.2021.07.028
URL الوصول: https://doaj.org/article/45b2cc0d19a84d7d8b40ff3be5dede53
رقم الأكسشن: edsdoj.45b2cc0d19a84d7d8b40ff3be5dede53
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:20010370
DOI:10.1016/j.csbj.2021.07.028