دورية أكاديمية
Human Leukocyte Antigens and Biomarkers in Type 1 Diabetes Mellitus Induced by Immune-Checkpoint Inhibitors
| العنوان: | Human Leukocyte Antigens and Biomarkers in Type 1 Diabetes Mellitus Induced by Immune-Checkpoint Inhibitors |
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| المؤلفون: | Hidefumi Inaba, Yosuke Kaido, Saya Ito, Tomonao Hirobata, Gen Inoue, Takakazu Sugita, Yuki Yamamoto, Masatoshi Jinnin, Hiroaki Kimura, Tomoko Kobayashi, Shintaro Iwama, Hiroshi Arima, Takaaki Matsuoka |
| المصدر: | Endocrinology and Metabolism, Vol 37, Iss 1, Pp 84-95 (2022) |
| بيانات النشر: | Korean Endocrine Society, 2022. |
| سنة النشر: | 2022 |
| المجموعة: | LCC:Diseases of the endocrine glands. Clinical endocrinology |
| مصطلحات موضوعية: | immune checkpoint inhibitors, immune-related adverse events, diabetes mellitus, type 1, biomarkers, cytokines, chemokines, Diseases of the endocrine glands. Clinical endocrinology, RC648-665 |
| الوصف: | Background Type 1 diabetes mellitus induced by immune-checkpoint inhibitors (ICI-T1DM) is a rare critical entity. However, the etiology of ICI-T1DM remains unclear. Methods In order to elucidate risk factors for ICI-T1DM, we evaluated the clinical course and immunological status of patients with ICI-T1DM who had been diagnosed during 2016 to 2021. Results Seven of 871 (0.8%, six men and one woman) patients developed ICI-T1DM. We revealed that the allele frequencies of human leukocyte antigen (HLA)-DPA1*02:02 and DPB1*05:01 were significantly higher in the patients with ICI-T1DM In comparison to the controls who received ICI (11/14 vs. 10/26, P=0.022; 11/14 vs. 7/26, P=0.0027, respectively). HLA-DRB1*04:05, which has been found to be a T1DM susceptibility allele in Asians, was also observed as a high-risk allele for ICI-T1DM. The significance of the HLA-DPB1*05:01 and DRB1*04:05 alleles was confirmed by an analysis of four additional patients. The absolute/relative neutrophil count, neutrophils-lymphocyte ratio, and neutrophil-eosinophil ratio increased, and the absolute lymphocyte count and absolute/relative eosinophil count decreased at the onset as compared with 6 weeks before. In two patients, alterations in cytokines and chemokines were found at the onset. Conclusion Novel high-risk HLA alleles and haplotypes were identified in ICI-T1DM, and peripheral blood factors may be utilized as biomarkers. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English Korean |
| تدمد: | 2093-596X 2093-5978 |
| Relation: | http://www.e-enm.org/upload/pdf/enm-2021-1282.pdf; https://doaj.org/toc/2093-596X; https://doaj.org/toc/2093-5978 |
| DOI: | 10.3803/EnM.2021.1282 |
| URL الوصول: | https://doaj.org/article/c45b318caf02452b8156842046da086d |
| رقم الأكسشن: | edsdoj.45b318caf02452b8156842046da086d |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 2093596X 20935978 |
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| DOI: | 10.3803/EnM.2021.1282 |