دورية أكاديمية
Long-term endocrine sequelae after hematopoietic stem cell transplantation in children and adolescents
| العنوان: | Long-term endocrine sequelae after hematopoietic stem cell transplantation in children and adolescents |
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| المؤلفون: | Soojin Hwang, Yena Lee, Ji-Hee Yoon, Ja Hye Kim, Hyery Kim, Kyung-Nam Koh, Ho Joon Im, Han-Wook Yoo, Jin-Ho Choi |
| المصدر: | Annals of Pediatric Endocrinology & Metabolism, Vol 29, Iss 2, Pp 109-118 (2024) |
| بيانات النشر: | Korean Society of Pediatric Endocrinology, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Pediatrics |
| مصطلحات موضوعية: | children, endocrine complication, hematopoietic stem cell transplantation, Pediatrics, RJ1-570 |
| الوصف: | Purpose As the survival rate from pediatric cancers has increased significantly with advances in treatment modalities, long-term endocrine complications have also risen. This study investigated the frequencies and risks of endocrine sequelae in childhood cancer survivors who received hematopoietic stem cell transplantation (HSCT). Methods This study included 200 pediatric patients who underwent HSCT. Clinical and endocrinological findings were collected retrospectively. The median follow-up duration after HSCT was 14 years. Results Endocrine complications occurred in 135 patients (67.5%). Children who underwent HSCT at pubertal age (n=100) were at higher risk of endocrine complications than those who received it at prepubertal age (79% vs. 56%, P=0.001). The most common complication was hypogonadism (40%), followed by dyslipidemia (22%). Short stature and diabetes mellitus were more prevalent in the prepubertal group, whereas hypogonadism and osteoporosis were more common in the pubertal group. Being female, pubertal age at HSCT, and glucocorticoid use were predictors of an increased risk for any complication. Radiation exposure increased the risk of short stature and hypothyroidism. Hypogonadism was significantly associated with being female, pubertal age at HSCT, and high-dose radiation. Pubertal age at HSCT also increased the risks of osteoporosis and dyslipidemia. Conclusions This study demonstrates that long-term endocrine complications are common after HSCT in children and adolescents. Age at HSCT is a critical factor for endocrine complications after HSCT. These findings suggest that surveillance strategies for endocrine complications in childhood cancer survivors should be specified according to age at HSCT. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2287-1012 2287-1292 |
| Relation: | http://e-apem.org/upload/pdf/apem-2346046-023.pdf; https://doaj.org/toc/2287-1012; https://doaj.org/toc/2287-1292 |
| DOI: | 10.6065/apem.2346046.023 |
| URL الوصول: | https://doaj.org/article/45ba5f228bd24dfb8feb491cffad4d4b |
| رقم الأكسشن: | edsdoj.45ba5f228bd24dfb8feb491cffad4d4b |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 22871012 22871292 |
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| DOI: | 10.6065/apem.2346046.023 |