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Development of Smart Composites Based on Doped-TiO2 Nanoparticles with Visible Light Anticancer Properties

التفاصيل البيبلوغرافية
العنوان: Development of Smart Composites Based on Doped-TiO2 Nanoparticles with Visible Light Anticancer Properties
المؤلفون: Evdokia Galata, Eleni A. Georgakopoulou, Maria-Emmanouela Kassalia, Nefeli Papadopoulou-Fermeli, Evangelia A. Pavlatou
المصدر: Materials, Vol 12, Iss 16, p 2589 (2019)
بيانات النشر: MDPI AG, 2019.
سنة النشر: 2019
المجموعة: LCC:Technology
LCC:Electrical engineering. Electronics. Nuclear engineering
LCC:Engineering (General). Civil engineering (General)
LCC:Microscopy
LCC:Descriptive and experimental mechanics
مصطلحات موضوعية: N-doped TiO2, Fe-doped TiO2, Fe,N-doped TiO2, sol gel, IP microgel, pNiPam, drug delivery, photocatalysis, visible light, anticancer, Technology, Electrical engineering. Electronics. Nuclear engineering, TK1-9971, Engineering (General). Civil engineering (General), TA1-2040, Microscopy, QH201-278.5, Descriptive and experimental mechanics, QC120-168.85
الوصف: In this study, the synthesis of smart, polymerically embedded titanium dioxide (TiO2) nanoparticles aimed to exhibit photo-induced anticancer properties under visible light irradiation is investigated. The TiO2 nanoparticles were prepared by utilizing the sol gel method with different dopants, including nitrogen (N-doped), iron (Fe-doped), and nitrogen and iron (Fe,N-doped). The dopants were embedded in an interpenetrating (IP) network microgel synthesized by stimuli responsive poly (N-Isopropylacrylamide-co-polyacrylicacid)−pNipam-co-PAA forming composite particles. All the types of produced particles were characterized by X-ray powder diffraction, micro-Raman, Fourier-transform infrared, X-ray photoelectron, ultra-violet-visible spectroscopy, Field Emission Scanning Electron, Transmission Electron microscopy, and Dynamic Light Scattering techniques. The experimental findings indicate that the doped TiO2 nanoparticles were successfully embedded in the microgel. The N-doped TiO2 nano-powders and composite particles exhibit the best photocatalytic degradation of the pollutant methylene blue under visible light irradiation. Similarly, the highly malignant MDA-MB-231 breast cancer epithelial cells were susceptible to the inhibition of cell proliferation at visible light, especially in the presence of N-doped powders and composites, compared to the non-metastatic MCF-7 cells, which were not affected.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1996-1944
Relation: https://www.mdpi.com/1996-1944/12/16/2589; https://doaj.org/toc/1996-1944
DOI: 10.3390/ma12162589
URL الوصول: https://doaj.org/article/45e5abfbd3da42438417b3ac82ab927d
رقم الأكسشن: edsdoj.45e5abfbd3da42438417b3ac82ab927d
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:19961944
DOI:10.3390/ma12162589