دورية أكاديمية
Mechanical Stretch Induced Skin Regeneration: Molecular and Cellular Mechanism in Skin Soft Tissue Expansion
العنوان: | Mechanical Stretch Induced Skin Regeneration: Molecular and Cellular Mechanism in Skin Soft Tissue Expansion |
---|---|
المؤلفون: | Yaotao Guo, Yajuan Song, Shaoheng Xiong, Tong Wang, Wei Liu, Zhou Yu, Xianjie Ma |
المصدر: | International Journal of Molecular Sciences, Vol 23, Iss 17, p 9622 (2022) |
بيانات النشر: | MDPI AG, 2022. |
سنة النشر: | 2022 |
المجموعة: | LCC:Biology (General) LCC:Chemistry |
مصطلحات موضوعية: | skin soft tissue expansion, mechanical stretch, signaling pathway, cell adhesion molecules, transcriptome sequencing, skin stem cell, Biology (General), QH301-705.5, Chemistry, QD1-999 |
الوصف: | Skin soft tissue expansion is one of the most basic and commonly used techniques in plastic surgery to obtain excess skin for a variety of medical uses. However, skin soft tissue expansion is faced with many problems, such as long treatment process, poor skin quality, high retraction rate, and complications. Therefore, a deeper understanding of the mechanisms of skin soft tissue expansion is needed. The key to skin soft tissue expansion lies in the mechanical stretch applied to the skin by an inflatable expander. Mechanical stimulation activates multiple signaling pathways through cellular adhesion molecules and regulates gene expression profiles in cells. Meanwhile, various types of cells contribute to skin expansion, including keratinocytes, dermal fibroblasts, and mesenchymal stem cells, which are also regulated by mechanical stretch. This article reviews the molecular and cellular mechanisms of skin regeneration induced by mechanical stretch during skin soft tissue expansion. |
نوع الوثيقة: | article |
وصف الملف: | electronic resource |
اللغة: | English |
تدمد: | 1422-0067 1661-6596 |
Relation: | https://www.mdpi.com/1422-0067/23/17/9622; https://doaj.org/toc/1661-6596; https://doaj.org/toc/1422-0067 |
DOI: | 10.3390/ijms23179622 |
URL الوصول: | https://doaj.org/article/45ecc5609e4748c1a3c4d13e59c6a841 |
رقم الأكسشن: | edsdoj.45ecc5609e4748c1a3c4d13e59c6a841 |
قاعدة البيانات: | Directory of Open Access Journals |
تدمد: | 14220067 16616596 |
---|---|
DOI: | 10.3390/ijms23179622 |