دورية أكاديمية
The role of SRC-3 in prostate cancer progression and implications for therapeutic targeting: A systematic review
| العنوان: | The role of SRC-3 in prostate cancer progression and implications for therapeutic targeting: A systematic review |
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| المؤلفون: | Suleiman Zakari, Wisdom D. Cleanclay, Mercy Bella-Omunagbe, Hajara Zakari, Celestine O. Ogbu, Daniel Ejim Uti, Olubanke O. Ogunlana |
| المصدر: | Journal of Pharmacy & Pharmacognosy Research, Vol 12, Iss 5, Pp 994-1007 (2024) |
| بيانات النشر: | GarVal Editorial Ltda., 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Therapeutics. Pharmacology LCC:Pharmacy and materia medica |
| مصطلحات موضوعية: | androgen receptor, signaling, prostate cancer, src-3, therapeutics, Therapeutics. Pharmacology, RM1-950, Pharmacy and materia medica, RS1-441 |
| الوصف: | Context: Prostate cancer remains a significant global health concern, and understanding the molecular drivers of this disease is crucial for developing effective diagnostic and therapeutic strategies. Steroid receptor coactivator-3 (SRC-3), a member of the SRC family, has emerged as a key player in prostate cancer pathogenesis. Aims: To examine the role of SRC-3 in prostate cancer, encompassing molecular mechanisms, clinical implications, and therapeutic opportunities. Methods: A systematic literature search following PRISMA guidelines was conducted in PubMed, PMC, and other relevant databases to identify studies that investigate SRC-3 in prostate cancer. Results: 785 articles were retrieved from databases using specific keywords and MeSH terms related to SRC-3 and Prostate Cancer. After removing 461 duplicates, 260 articles were excluded based on title and abstract review. Subsequently, a comprehensive screening by three researchers resulted in 47 relevant articles for this systematic review. Evidence suggests that SRC-3 expression correlates with prostate cancer aggressiveness, disease recurrence, and poor patient outcomes. Its potential as a diagnostic biomarker and therapeutic target if explored, offers insights into personalized medicine approaches. Conclusions: SRC-3 plays a pivotal role in prostate cancer, influencing disease progression and clinical outcomes. Understanding the molecular intricacies of SRC-3 in prostate cancer offers new opportunities for precision medicine and innovative therapeutic approaches. This review provides a comprehensive overview of SRC-3's involvement in prostate cancer, emphasizing its clinical relevance and potential as a therapeutic target, ultimately contributing to improved patient care in the era of personalized oncology. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English Spanish; Castilian |
| تدمد: | 0719-4250 |
| Relation: | https://jppres.com/jppres/pdf/vol12/jppres23.1916_12.5.994.pdf; https://doaj.org/toc/0719-4250 |
| DOI: | 10.56499/jppres23.1916_12.5.994 |
| URL الوصول: | https://doaj.org/article/464d0338bb0e4291876c2a7d089c1946 |
| رقم الأكسشن: | edsdoj.464d0338bb0e4291876c2a7d089c1946 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 07194250 |
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| DOI: | 10.56499/jppres23.1916_12.5.994 |