دورية أكاديمية
Elevated ApoB/apoA-1 is Associated with in-Hospital Mortality in Elderly Patients with Acute Myocardial Infarction
العنوان: | Elevated ApoB/apoA-1 is Associated with in-Hospital Mortality in Elderly Patients with Acute Myocardial Infarction |
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المؤلفون: | Chen Y, Chen S, Han Y, Xu Q, Zhao X |
المصدر: | Diabetes, Metabolic Syndrome and Obesity, Vol Volume 16, Pp 3501-3512 (2023) |
بيانات النشر: | Dove Medical Press, 2023. |
سنة النشر: | 2023 |
المجموعة: | LCC:Specialties of internal medicine |
مصطلحات موضوعية: | elderly, apolipoprotein, acute myocardial infarction, in-hospital death, restricted cubic splines, Specialties of internal medicine, RC581-951 |
الوصف: | Yan Chen, Shengyue Chen, Yuanyuan Han, Qing Xu, Xin Zhao Department of Cardiology, The Second Hospital of Dalian Medical University, Dalian, People’s Republic of ChinaCorrespondence: Xin Zhao, Department of Cardiology, The Second Hospital of Dalian Medical University, No. 467 Zhongshan Road, Shahekou District, Dalian, 116023, People’s Republic of China, Tel +86-0411-84671291, Email zx81830@163.comBackground: Apolipoprotein B/apolipoprotein A-1 (apoB/apoA-1) has been shown to be strongly associated with the risk of future cardiovascular disease, but the association between apoB/apoA-1 and the risk of in-hospital death in elderly patients with acute myocardial infarction(AMI) is inconclusive.Aim: To investigate the association between apoB/apoA-1 and the risk of in-hospital death in elderly patients with AMI.Methods: From December 2015 to December 2021, a total of 1495 elderly AMI patients (aged ≥ 60 years) with complete clinical history data were enrolled in the Second Hospital of Dalian Medical University. Outcome was defined as all-cause mortality during hospitalization. Multivariate logistic regression and restricted spline cubic (RCS) models were used to evaluate the association between apoB/apoA-1 and in-hospital mortality risk, respectively. Receiver operating characteristic(ROC) curves were used to evaluate the predictive value of apoB/apoA-1 for in-hospital mortality events. Discordance analysis was performed when apoB/apoA-1 and LDL-C/HDL-C were not in concordance.Results: (1) A total of 128 patients (8.6%) died during hospitalization. Patients in the death group had higher apoB/apoA-1 than those in the non-death group, but lower apoA-1 levels than those in the non-death group, and the difference was statistically significant (P < 0.05); (2) Multivariate logistic regression analysis showed that apoB/apoA-1 was associated with the risk of in-hospital death in elderly AMI patients [Model 3 OR = 3.524 (1.622– 7.659), P = 0.001]; (3) ROC curve analysis showed that apoB/apoA-1 (AUC = 0.572, P = 0.011) had some predictive value for the risk of in-hospital death in elderly AMI patients; (4) RCS models showed a linear dose-response relationship between apoB/apoA-1 and in-hospital death after adjusting for confounders (P for non-linearity = 0.762).Conclusion: ApoB/apoA-1 is associated with the risk of in-hospital death in elderly patients with AMI, and is superior to other blood lipid parameters and blood lipid ratio.Keywords: elderly, apolipoprotein, acute myocardial infarction, in-hospital death, restricted cubic splines |
نوع الوثيقة: | article |
وصف الملف: | electronic resource |
اللغة: | English |
تدمد: | 1178-7007 46660690 |
Relation: | https://www.dovepress.com/elevated-apobapoa-1-is-associated-with-in-hospital-mortality-in-elderl-peer-reviewed-fulltext-article-DMSO; https://doaj.org/toc/1178-7007 |
URL الوصول: | https://doaj.org/article/466606906c854720bb183189f25c4e9b |
رقم الأكسشن: | edsdoj.466606906c854720bb183189f25c4e9b |
قاعدة البيانات: | Directory of Open Access Journals |
تدمد: | 11787007 46660690 |
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