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Precision nephrotoxicity testing using 3D in vitro models

التفاصيل البيبلوغرافية
العنوان: Precision nephrotoxicity testing using 3D in vitro models
المؤلفون: Pengfei Yu, Hainan Zhu, Carol Christine Bosholm, Daniella Beiner, Zhongping Duan, Avinash K. Shetty, Steve S. Mou, Philip Adam Kramer, Luis F. Barroso, Hongbing Liu, Kun Cheng, Michael Ihnat, Matthew A. Gorris, Joseph A. Aloi, Jobira A. Woldemichael, Anthony Bleyer, Yuanyuan Zhang
المصدر: Cell & Bioscience, Vol 13, Iss 1, Pp 1-16 (2023)
بيانات النشر: BMC, 2023.
سنة النشر: 2023
المجموعة: LCC:Biotechnology
LCC:Biology (General)
LCC:Biochemistry
مصطلحات موضوعية: Precision medicine, Nephrotoxicity, Drug toxicity testing, 3D culture model, Human primary renal cells, Biotechnology, TP248.13-248.65, Biology (General), QH301-705.5, Biochemistry, QD415-436
الوصف: Abstract Nephrotoxicity is a significant concern during the development of new drugs or when assessing the safety of chemicals in consumer products. Traditional methods for testing nephrotoxicity involve animal models or 2D in vitro cell cultures, the latter of which lack the complexity and functionality of the human kidney. 3D in vitro models are created by culturing human primary kidney cells derived from urine in a 3D microenvironment that mimics the fluid shear stresses of the kidney. Thus, 3D in vitro models provide more accurate and reliable predictions of human nephrotoxicity compared to existing 2D models. In this review, we focus on precision nephrotoxicity testing using 3D in vitro models with human autologous urine-derived kidney cells as a promising approach for evaluating drug safety.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2045-3701
Relation: https://doaj.org/toc/2045-3701
DOI: 10.1186/s13578-023-01187-0
URL الوصول: https://doaj.org/article/46ca9ddf32404e8e9e1293635bb4642b
رقم الأكسشن: edsdoj.46ca9ddf32404e8e9e1293635bb4642b
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:20453701
DOI:10.1186/s13578-023-01187-0