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Irbesartan ameliorates chronic mountain sickness in a rat model via the cholesterol metabolism: An iTRAQ -based proteomics analysis

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العنوان: Irbesartan ameliorates chronic mountain sickness in a rat model via the cholesterol metabolism: An iTRAQ -based proteomics analysis
المؤلفون: Yiliyaer Nijiati, Tao Yang, Mutalifu Aimaiti, Dilinuer Maimaitiyiming, Ainiwaer Aikemu
المصدر: Biomedicine & Pharmacotherapy, Vol 141, Iss , Pp 111802- (2021)
بيانات النشر: Elsevier, 2021.
سنة النشر: 2021
المجموعة: LCC:Therapeutics. Pharmacology
مصطلحات موضوعية: Chronic mountain sickness, Irbesartan, ITRAQ-based proteomics, Biomarkers, Cholesterol Metabolism, Therapeutics. Pharmacology, RM1-950
الوصف: Objective: To study the effects of irbesartan on pulmonary artery lesions in a rat model with chronic mountain sickness (CMS) and identify the biomarkers involved. Methods: In this study, we used a rat model of CMS to evaluate the therapeutic effect of irbesartan by measuring pulmonary artery pressure and evaluating the histopathology of the pulmonary artery. We also used proteomics technology to identify differentially expressed proteins (DEPs) in the serum and performed bioinformatics analysis. Results were then verified by enzyme linked immunosorbent assay (ELISA) and immunohistochemistry (IHC). Results: Irbesartan treatment induced a significant decrease (P
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 0753-3322
Relation: http://www.sciencedirect.com/science/article/pii/S0753332221005849; https://doaj.org/toc/0753-3322
DOI: 10.1016/j.biopha.2021.111802
URL الوصول: https://doaj.org/article/46d3b6a1142040888e79df63878ccc4f
رقم الأكسشن: edsdoj.46d3b6a1142040888e79df63878ccc4f
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:07533322
DOI:10.1016/j.biopha.2021.111802