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Serum levels of IL-17, IL-4, and INFγ in Serbian patients with early rheumatoid arthritis

التفاصيل البيبلوغرافية
العنوان: Serum levels of IL-17, IL-4, and INFγ in Serbian patients with early rheumatoid arthritis
المؤلفون: Voja Pavlovic, Aleksandar Dimic, Sasa Milenkovic, Dane Krtinic
المصدر: Journal of Research in Medical Sciences, Vol 19, Iss 1, Pp 18-22 (2014)
بيانات النشر: Wolters Kluwer Medknow Publications, 2014.
سنة النشر: 2014
المجموعة: LCC:Medicine
مصطلحات موضوعية: Early rheumatoid arthritis, IL-17A, IL-4, INFγ, Medicine
الوصف: Background: Rheumatoid arthritis (RA) is a chronic, systemic, inflammatory disease with autoimmune etiology, characterized by synovial inflammation and destruction of joint cartilage and bone. There are controversial data about the profile of interleukin-17 (IL-17A), interleukin-4 (IL-4), and interferon-gamma (INFγ), indicating in some studies the key role of IL-17, while in others the Th1 cytokines. Materials and Methods: Serum samples of 31 early RA patients were evaluated for erythrocytes sedimentation rate (ESR), rheumatoid factor (RF), C-reactive protein (CRP), anti-cyclic citrullinated peptide antibodies (anti-CCP), and for the tested cytokines (IL-17A, IL-4, and INFγ). Disease activity score (DAS28) calculation was done for all patients. Control serum samples were obtained from 29 healthy volunteers. Results: The levels of tested cytokines were significantly higher (IL-17A, p < 0.001; INFγ, p < 0.001; IL-4, p < 0.01) in patients with early RA, compared to the healthy controls. In early RA patients, a strong correlation of serum IL-17A was found with DAS28, ESR, and CRP. Also, significant negative correlation was found between serum INFγ levels and the DAS28 score, indicating that INFγ may play a key role in maintaining immune homeostasis in patients with RA. Conclusion: The mean serum IL-17A levels in patients with early RA, corresponded with the disease activity and severity. This might highlight the usefulness of the serum IL-17A level in defining the activity and predictive patterns, for aggressive disease therapy, and it might express specific therapeutically targets.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1735-1995
1735-7136
Relation: http://www.jmsjournal.net/article.asp?issn=1735-1995;year=2014;volume=19;issue=1;spage=18;epage=22;aulast=Pavlovic; https://doaj.org/toc/1735-1995; https://doaj.org/toc/1735-7136
URL الوصول: https://doaj.org/article/46e4b5ecf08241c2b182f0987ce31453
رقم الأكسشن: edsdoj.46e4b5ecf08241c2b182f0987ce31453
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:17351995
17357136