دورية أكاديمية
Serum penicillin G levels are lower than expected in adults within two weeks of administration of 1.2 million units.
| العنوان: | Serum penicillin G levels are lower than expected in adults within two weeks of administration of 1.2 million units. |
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| المؤلفون: | Michael P Broderick, Christian J Hansen, Kevin L Russell, Edward L Kaplan, Jeffrey L Blumer, Dennis J Faix |
| المصدر: | PLoS ONE, Vol 6, Iss 10, p e25308 (2011) |
| بيانات النشر: | Public Library of Science (PLoS), 2011. |
| سنة النشر: | 2011 |
| المجموعة: | LCC:Medicine LCC:Science |
| مصطلحات موضوعية: | Medicine, Science |
| الوصف: | When introduced in the 1950s, benzathine penicillin G (BPG) was shown to be effective in eradicating group A beta-hemolytic streptococcus (GAS) for at least 3 weeks after administration. Several studies since the 1990s suggest that at 3-4 weeks serum penicillin G levels are less than adequate (below MIC(90) of 0.016 µg/ml). We studied these levels for 4 weeks after the recommended dose of BPG in military recruits, for whom it is used as prophylaxis against GAS. The 329 subjects (mean age 20 years) each received 1.2 million units BPG IM and gave sera 1 day post injection and twice more at staggered time points over 4 weeks. Serum penicillin G levels were measured by liquid chromatography/tandem mass spectometry. The half-life of serum penicillin G was 4.1 days. By day 11, mean levels were |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1932-6203 |
| Relation: | http://europepmc.org/articles/PMC3186770?pdf=render; https://doaj.org/toc/1932-6203 |
| DOI: | 10.1371/journal.pone.0025308 |
| URL الوصول: | https://doaj.org/article/c4719a23f51d42fbb2773f31f8501b28 |
| رقم الأكسشن: | edsdoj.4719a23f51d42fbb2773f31f8501b28 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 19326203 |
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| DOI: | 10.1371/journal.pone.0025308 |