دورية أكاديمية
Ferroptosis: a promising candidate for exosome-mediated regulation in different diseases
| العنوان: | Ferroptosis: a promising candidate for exosome-mediated regulation in different diseases |
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| المؤلفون: | Limin Liu, Yulin Ye, Rui Lin, Tianyu Liu, Sinan Wang, Zelin Feng, Xiaoli Wang, Hailong Cao, Xin Chen, Junming Miao, Yifei Liu, Kui Jiang, Zhibo Han, Zongjin Li, Xiaocang Cao |
| المصدر: | Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-15 (2024) |
| بيانات النشر: | BMC, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Medicine LCC:Cytology |
| مصطلحات موضوعية: | Exosomes, Stem cells, Ferroptosis, Therapeutic target, Signalling pathway, Iron metabolism, Medicine, Cytology, QH573-671 |
| الوصف: | Abstract Ferroptosis is a newly discovered form of cell death that is featured in a wide range of diseases. Exosome therapy is a promising therapeutic option that has attracted much attention due to its low immunogenicity, low toxicity, and ability to penetrate biological barriers. In addition, emerging evidence indicates that exosomes possess the ability to modulate the progression of diverse diseases by regulating ferroptosis in damaged cells. Hence, the mechanism by which cell-derived and noncellular-derived exosomes target ferroptosis in different diseases through the system Xc−/GSH/GPX4 axis, NAD(P)H/FSP1/CoQ10 axis, iron metabolism pathway and lipid metabolism pathway associated with ferroptosis, as well as its applications in liver disease, neurological diseases, lung injury, heart injury, cancer and other diseases, are summarized here. Additionally, the role of exosome-regulated ferroptosis as an emerging repair mechanism for damaged tissues and cells is also discussed, and this is expected to be a promising treatment direction for various diseases in the future. Video Abstract |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1478-811X |
| Relation: | https://doaj.org/toc/1478-811X |
| DOI: | 10.1186/s12964-023-01369-w |
| URL الوصول: | https://doaj.org/article/473882418c114cca9cc6e9c7d8e78abe |
| رقم الأكسشن: | edsdoj.473882418c114cca9cc6e9c7d8e78abe |
| قاعدة البيانات: | Directory of Open Access Journals |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 1478811X |
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| DOI: | 10.1186/s12964-023-01369-w |