دورية أكاديمية
أعرض في EDS

Association between carotid plaque characteristics and cerebral white matter lesions: one-year follow-up study by MRI.

التفاصيل البيبلوغرافية
العنوان: Association between carotid plaque characteristics and cerebral white matter lesions: one-year follow-up study by MRI.
المؤلفون: Robert M Kwee, Paul A M Hofman, Ed H B M Gronenschild, Robert J van Oostenbrugge, Werner H Mess, Johannes W M ter Berg, Cees L Franke, Arthur G G C Korten, Bé J Meems, Jos M A van Engelshoven, Joachim E Wildberger, M Eline Kooi
المصدر: PLoS ONE, Vol 6, Iss 2, p e17070 (2011)
بيانات النشر: Public Library of Science (PLoS), 2011.
سنة النشر: 2011
المجموعة: LCC:Medicine
LCC:Science
مصطلحات موضوعية: Medicine, Science
الوصف: OBJECTIVE: To prospectively assess the relation between carotid plaque characteristics and the development of new cerebral white matter lesions (WMLs) at MRI. METHODS: Fifty TIA/stroke patients with ipsilateral 30-69% carotid stenosis underwent MRI of the plaque at baseline. Total plaque volume and markers of vulnerability to thromboembolism (lipid-rich necrotic core [LRNC] volume, fibrous cap [FC] status, and presence of intraplaque hemorrhage [IPH]) were assessed. All patients also underwent brain MRI at baseline and after one year. Ipsilateral cerebral WMLs were quantified with a semiautomatic method. RESULTS: Mean WML volume significantly increased over a one-year period (6.52 vs. 6.97 mm(3), P = 0.005). WML volume at baseline and WML progression did not significantly differ (P>0.05) between patients with 30-49% and patients with 50-69% stenosis. There was a significant correlation between total plaque volume and baseline ipsilateral WML volume (Spearman ρ = 0.393, P = 0.005). There was no significant correlation between total plaque volume and ipsilateral WML progression. There were no significant associations between LRNC volume and WML volume at baseline and WML progression. WML volume at baseline and WML progression did not significantly differ between patients with a thick and intact FC and patients with a thin and/or ruptured FC. WML volume at baseline and WML progression also did not significantly differ between patients with and without IPH. CONCLUSION: The results of this study indicate that carotid plaque burden is significantly associated with WML severity, but that there is no causal relationship between carotid plaque vulnerability and the occurrence of WMLs.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1932-6203
Relation: http://europepmc.org/articles/PMC3039645?pdf=render; https://doaj.org/toc/1932-6203
DOI: 10.1371/journal.pone.0017070
URL الوصول: https://doaj.org/article/4754342ec25d4259b339822188b2c771
رقم الأكسشن: edsdoj.4754342ec25d4259b339822188b2c771
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:19326203
DOI:10.1371/journal.pone.0017070