دورية أكاديمية
New Viral Facets in Oral Diseases: The EBV Paradox
| العنوان: | New Viral Facets in Oral Diseases: The EBV Paradox |
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| المؤلفون: | Lilit Tonoyan, Séverine Vincent-Bugnas, Charles-Vivien Olivieri, Alain Doglio |
| المصدر: | International Journal of Molecular Sciences, Vol 20, Iss 23, p 5861 (2019) |
| بيانات النشر: | MDPI AG, 2019. |
| سنة النشر: | 2019 |
| المجموعة: | LCC:Biology (General) LCC:Chemistry |
| مصطلحات موضوعية: | epstein–barr virus, lichen planus oral, periodontal diseases, sjogren’s syndrome, etiopathogenesis of oral inflammatory diseases, viral-bacterial synergism, plasma cells, Biology (General), QH301-705.5, Chemistry, QD1-999 |
| الوصف: | The oral cavity contributes to overall health, psychosocial well-being and quality of human life. Oral inflammatory diseases represent a major global health problem with significant social and economic impact. The development of effective therapies, therefore, requires deeper insights into the etiopathogenesis of oral diseases. Epstein−Barr virus (EBV) infection results in a life-long persistence of the virus in the host and has been associated with numerous oral inflammatory diseases including oral lichen planus (OLP), periodontal disease and Sjogren’s syndrome (SS). There is considerable evidence that the EBV infection is a strong risk factor for the development and progression of these conditions, but is EBV a true pathogen? This long-standing EBV paradox yet needs to be solved. This review discusses novel viral aspects of the etiopathogenesis of non-tumorigenic diseases in the oral cavity, in particular, the contribution of EBV in OLP, periodontitis and SS, the tropism of EBV infection, the major players involved in the etiopathogenic mechanisms and emerging contribution of EBV-pathogenic bacteria bidirectional interaction. It also proposes the involvement of EBV-infected plasma cells in the development and progression of oral inflammatory diseases. A new direction for preventing and treating these conditions may focus on controlling pathogenic EBV with anti-herpetic drugs. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1422-0067 |
| Relation: | https://www.mdpi.com/1422-0067/20/23/5861; https://doaj.org/toc/1422-0067 |
| DOI: | 10.3390/ijms20235861 |
| URL الوصول: | https://doaj.org/article/477995dddc71448fbea2aedf214df986 |
| رقم الأكسشن: | edsdoj.477995dddc71448fbea2aedf214df986 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 14220067 |
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| DOI: | 10.3390/ijms20235861 |