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Development of an IFNγ response‐related signature for predicting the survival of cutaneous melanoma

التفاصيل البيبلوغرافية
العنوان: Development of an IFNγ response‐related signature for predicting the survival of cutaneous melanoma
المؤلفون: Baohui Hu, Qian Wei, Xueping Li, Mingyi Ju, Lin Wang, Chenyi Zhou, Lianze Chen, Zinan Li, Minjie Wei, Miao He, Lin Zhao
المصدر: Cancer Medicine, Vol 9, Iss 21, Pp 8186-8201 (2020)
بيانات النشر: Wiley, 2020.
سنة النشر: 2020
المجموعة: LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
مصطلحات موضوعية: GEO, IFNγ response, prognosis, skin cutaneous melanoma, TCGA, tumor microenvironment, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
الوصف: Abstract Background The tumor microenvironment (TME) plays a critical role in tumorigenesis, development, and therapeutic efficacy. Major advances have been achieved in the treatment of various cancers through immunotherapy. Nevertheless, only a minority of patients have positive responses to immunotherapy, which is partly due to conditions of the immunosuppressive microenvironment. Therefore, it is essential to identify prognostic biomarkers that reflect heterogeneous landscapes of the TME. Methods and materials Based upon the ESTIMATE algorithm, we evaluated the infiltrating levels of immune and stromal components derived from patients afflicted by various types of cancer from The Cancer Genome Atlas database (TCGA). According to respective patient immune and stromal scores, we categorized cases into high‐ and low‐scoring subgroups for each cancer type to explore associations between TME and patient prognosis. Gene Set Enrichment Analyses (GSEA) were conducted and genes enriched in IFNγ response signaling pathway were selected to facilitate establishment of a risk model for predicting overall survival (OS). Furthermore, we investigated the associations between the prognostic signature and tumor immune infiltration landscape by using CIBERSORT algorithm and TIMER database. Results Among the cancers assessed, the immune scores for skin cutaneous melanoma (SKCM) were the most significantly correlated with patients' survival time (P
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2045-7634
65621247
Relation: https://doaj.org/toc/2045-7634
DOI: 10.1002/cam4.3438
URL الوصول: https://doaj.org/article/47994d6562124788a65516c7c584d23d
رقم الأكسشن: edsdoj.47994d6562124788a65516c7c584d23d
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:20457634
65621247
DOI:10.1002/cam4.3438