دورية أكاديمية
أعرض في EDS

Urinary Marinobufagenin in Patients with Non-Advanced Chronic Kidney Disease: A Cross-Sectional Study

التفاصيل البيبلوغرافية
العنوان: Urinary Marinobufagenin in Patients with Non-Advanced Chronic Kidney Disease: A Cross-Sectional Study
المؤلفون: Davide Bolignano, Marta Greco, Mario D’Agostino, Paola Cianfrone, Loredana Tripodi, Roberta Misiti, Mariateresa Zicarelli, Ludovica Ganino, Daniela Patrizia Foti, Michele Andreucci, Giuseppe Coppolino
المصدر: Medicina, Vol 59, Iss 8, p 1392 (2023)
بيانات النشر: MDPI AG, 2023.
سنة النشر: 2023
المجموعة: LCC:Medicine (General)
مصطلحات موضوعية: marinobufagenin, chronic kidney disease, biomarker, Medicine (General), R5-920
الوصف: Background and Objectives: The global prevalence of chronic kidney disease (CKD) is on the rise, posing important challenges for healthcare systems. Thus, the search for new factors potentially involved in the pathogenesis, progression and complications of early CKD remains urgent. Marinobufagenin (MBG) is a natriuretic endogenous cardiotonic steroid, and increased circulating levels of it may accelerate kidney damage. In this study, we explored the possible clinical significance of measuring urinary marinobufagenin (uMBG) in patients with non-advanced CKD. Materials and Methods: One hundred and eight adult CKD patients (mean age 71.6 ± 10 years, 70.4% male; mean eGFR 40.54 ± 17 mL/min/1.73 m2) were enrolled in this cross-sectional study. uMBG was measured together with a series of clinical, anthropometric, laboratory and instrumental analyses. Twenty-five healthy matched subjects served as controls for the uMBG measurement. Results: The uMBG values were lower in the patients with CKD as compared to those of the controls (0.37 [IQR: 0.25–0.45] vs. 0.64 [0.46–0.78] nmol/L. p = 0.004), and a significant trend in eGFR levels was noticed across the decreasing uMBG tertiles (p = 0.03). Regarding the correlation analyses, the uMBG values remained robustly associated with the eGFR in multivariate models employing either uMBG or eGFR as the dependent variable (β = 0.248; p = 0.01 and β = 0.139; p = 0.04, respectively). Besides the eGFR, the independent predictors of uMBG values in this population were the use of statins (β = −0.326; p = 0.001), the presence of diabetes (β = 0.243; p = 0.009) and urine sodium (β = 0.204; p = 0.01). Conclusions: Reduced uMBG excretion may reflect impaired renal clearance, which may contribute to the detrimental effects attributed to this hormone due to systemic accumulation. Future studies are needed to clarify the biological mechanisms placing uMBG at the crossroad of sodium intake and the presence of diabetes in CKD-suffering individuals and to verify whether a statin treatment may somewhat limit the detrimental effects of MBG in the presence of impaired renal function.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 59081392
1648-9144
1010-660X
Relation: https://www.mdpi.com/1648-9144/59/8/1392; https://doaj.org/toc/1010-660X; https://doaj.org/toc/1648-9144
DOI: 10.3390/medicina59081392
URL الوصول: https://doaj.org/article/47ba8e3c363a4bc89cef6154b03dade0
رقم الأكسشن: edsdoj.47ba8e3c363a4bc89cef6154b03dade0
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:59081392
16489144
1010660X
DOI:10.3390/medicina59081392