دورية أكاديمية
Sudden cardiac death of Duchenne muscular dystrophy with NT-proBNP in pericardial fluid as a useful biomarker for diagnosis of the cause of death: a case report
| العنوان: | Sudden cardiac death of Duchenne muscular dystrophy with NT-proBNP in pericardial fluid as a useful biomarker for diagnosis of the cause of death: a case report |
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| المؤلفون: | Mengzhou Zhang, Rui Zhao, Tianshui Yu, Jiaoyong Li, Miao Zhang, Shukun Jiang, Linlin Wang, Guohua Zhang, Rubo Li, Baoli Zhu, Dawei Guan |
| المصدر: | Forensic Sciences Research, Vol 5, Iss 2, Pp 165-169 (2020) |
| بيانات النشر: | Oxford University Press, 2020. |
| سنة النشر: | 2020 |
| المجموعة: | LCC:Criminal law and procedure LCC:Public aspects of medicine |
| مصطلحات موضوعية: | forensic medicine, nt-probnp, sudden cardiac death, duchenne muscular dystrophy, left ventricular dysfunction, Criminal law and procedure, K5000-5582, Public aspects of medicine, RA1-1270 |
| الوصف: | Duchenne muscular dystrophy (DMD) is one of the most common and severest muscular dystrophies. Although it can be a cause of death when associated with cardiac muscle and/or respiratory muscles, no cases of sudden deaths in the setting of undiagnosed DMD with cardiac involvement have been reported in the literatures. Previous studies showed that N-terminal-proBNP (NT-proBNP) was a robust laboratory biomarker to diagnose and monitor cardiac failure in clinical situations, suggesting that it may be used as an auxiliary indicator for diagnosis on left ventricular dysfunction in sudden cardiac deaths in forensic settings. Here, we reported a case of 29-year-old man who died suddenly. Autopsy revealed that muscles of the body were almost replaced by fatty and fibrotic tissues. The heart was enlarged with disarray and degeneration of cardiomyocytes in cardiac muscle. Total absence of dystrophin was detected by immunohistochemical staining, which confirmed DMD. Postmortem biochemical test of pericardial fluid revealed a high level of NT-proBNP, indicating dysfunction of the left ventricle before death. The cause of death was certified as an early dilated cardiomyopathy (DCM)/dysfunction of the left ventricle secondary to DMD, suggesting that sudden cardiac death with cardiac dysfunction could be identified by immunohistochemical method in combination with pericardial fluid NT-proBNP determination after systemic autopsy. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2096-1790 2471-1411 20961790 |
| Relation: | https://doaj.org/toc/2096-1790; https://doaj.org/toc/2471-1411 |
| DOI: | 10.1080/20961790.2017.1333249 |
| URL الوصول: | https://doaj.org/article/ece48067a6c643b6b15f910481746ce6 |
| رقم الأكسشن: | edsdoj.48067a6c643b6b15f910481746ce6 |
| قاعدة البيانات: | Directory of Open Access Journals |
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Full Text Finder | تدمد: | 20961790 24711411 |
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| DOI: | 10.1080/20961790.2017.1333249 |