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Renal biopsies from donors with acute kidney injury show different molecular patterns according to the post-transplant function

التفاصيل البيبلوغرافية
العنوان: Renal biopsies from donors with acute kidney injury show different molecular patterns according to the post-transplant function
المؤلفون: Flavia Neri, Maria Letizia Lo Faro, Maria Kaisar, Ka Ho Tam, Martyna Borak, Jan Lindeman, Annalisa Angelini, Marny Fedrigo, Jesper Kers, James Hunter, Rutger Ploeg
المصدر: Scientific Reports, Vol 14, Iss 1, Pp 1-9 (2024)
بيانات النشر: Nature Portfolio, 2024.
سنة النشر: 2024
المجموعة: LCC:Medicine
LCC:Science
مصطلحات موضوعية: Medicine, Science
الوصف: Abstract The utilization of kidneys from donors with acute kidney injury (AKI) is often limited by unpredictable post-transplantation outcomes. The aim of our study was to identify protein mediators implicated in either recovery or failure of these organs. Forty kidney biopsies from donors with (20) and without AKI (20) were selected and then subdivided according to the post-transplant outcome defined as a threshold of 45 ml/min for the eGFR at 1 year from transplantation. Tissue homogenates were analysed by western blot to assess how the levels of 17 pre-selected proteins varied across the four groups. Samples from AKI kidneys with a poor outcome showed a fourfold increase in the levels of PPARg and twofold reduction of STAT1 compared to the other groups (p
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2045-2322
Relation: https://doaj.org/toc/2045-2322
DOI: 10.1038/s41598-024-56277-x
URL الوصول: https://doaj.org/article/a4815eee77584637b463c650c51d0755
رقم الأكسشن: edsdoj.4815eee77584637b463c650c51d0755
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:20452322
DOI:10.1038/s41598-024-56277-x