دورية أكاديمية
Emerging roles of lactate in acute and chronic inflammation
| العنوان: | Emerging roles of lactate in acute and chronic inflammation |
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| المؤلفون: | Yunda Fang, Zhengjun Li, Lili Yang, Wen Li, Yutong Wang, Ziyang Kong, Jia Miao, Yanqi Chen, Yaoyao Bian, Li Zeng |
| المصدر: | Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-22 (2024) |
| بيانات النشر: | BMC, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Medicine LCC:Cytology |
| مصطلحات موضوعية: | Inflammatory response, Lactate metabolism, Lactylation, Lactate clock, Glycolysis, Medicine, Cytology, QH573-671 |
| الوصف: | Abstract Traditionally, lactate has been considered a ‘waste product’ of cellular metabolism. Recent findings have shown that lactate is a substance that plays an indispensable role in various physiological cellular functions and contributes to energy metabolism and signal transduction during immune and inflammatory responses. The discovery of lactylation further revealed the role of lactate in regulating inflammatory processes. In this review, we comprehensively summarize the paradoxical characteristics of lactate metabolism in the inflammatory microenvironment and highlight the pivotal roles of lactate homeostasis, the lactate shuttle, and lactylation (‘lactate clock’) in acute and chronic inflammatory responses from a molecular perspective. We especially focused on lactate and lactate receptors with either proinflammatory or anti-inflammatory effects on complex molecular biological signalling pathways and investigated the dynamic changes in inflammatory immune cells in the lactate-related inflammatory microenvironment. Moreover, we reviewed progress on the use of lactate as a therapeutic target for regulating the inflammatory response, which may provide a new perspective for treating inflammation-related diseases. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1478-811X |
| Relation: | https://doaj.org/toc/1478-811X |
| DOI: | 10.1186/s12964-024-01624-8 |
| URL الوصول: | https://doaj.org/article/4835082e6a8244a29404cfa159aef978 |
| رقم الأكسشن: | edsdoj.4835082e6a8244a29404cfa159aef978 |
| قاعدة البيانات: | Directory of Open Access Journals |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 1478811X |
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| DOI: | 10.1186/s12964-024-01624-8 |