دورية أكاديمية
Acinetobacter quorum sensing contributes to inflammation-induced inhibition of orthopaedic implant osseointegration
| العنوان: | Acinetobacter quorum sensing contributes to inflammation-induced inhibition of orthopaedic implant osseointegration |
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| المؤلفون: | H Choe, BS Hausman, KM Hujer, O Akkus, PN Rather, Z Lee, RA Bonomo, EM Greenfield |
| المصدر: | European Cells & Materials, Vol 43, Pp 267-276 (2022) |
| بيانات النشر: | Forum Multimedia Publishing LLC, 2022. |
| سنة النشر: | 2022 |
| المجموعة: | LCC:Diseases of the musculoskeletal system LCC:Orthopedic surgery |
| مصطلحات موضوعية: | artificial ligament, polyethylene terephthalate, profiled filaments, calcium phosphate, ligamentisation, Diseases of the musculoskeletal system, RC925-935, Orthopedic surgery, RD701-811 |
| الوصف: | Implant infection impairs osseointegration of orthopaedic implants by inducing inflammation. Acinetobacter spp. are increasingly prevalent multi-drug resistant bacteria that can cause osteomyelitis. Acinetobacter spp. can also cause inflammation and thereby inhibit osseointegration in mice. The purpose of the present study was to investigate the role of quorum sensing in this context. Therefore, wild-type bacteria were compared with an isogenic abaI mutant defective in quorum sensing in a murine osseointegration model. The abaI quorum- sensing mutant affected significantly less osseointegration and interleukin (IL) 1β levels, without detectably altering other pro-inflammatory cytokines. Wild-type bacteria had fewer effects on IL1 receptor (IL1R)−/− mice. These results indicated that quorum sensing in Acinetobacter spp. contributed to IL1β induction and the resultant inhibition of osseointegration in mice. Moreover, targeting the Gram-negative acyl-homoserine lactone quorum sensing may be particularly effective for patients with Acinetobacter spp. infections. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1473-2262 |
| Relation: | https://www.ecmjournal.org/papers/vol043/pdf/v043a18.pdf; https://doaj.org/toc/1473-2262 |
| DOI: | 10.22203/eCM.v043a18 |
| URL الوصول: | https://doaj.org/article/c48469a1b84846fb9000b8a7bad2d0bb |
| رقم الأكسشن: | edsdoj.48469a1b84846fb9000b8a7bad2d0bb |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 14732262 |
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| DOI: | 10.22203/eCM.v043a18 |