دورية أكاديمية
Antiprotozoal and molluscicidal activities of five Brazilian plants
| العنوان: | Antiprotozoal and molluscicidal activities of five Brazilian plants |
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| المؤلفون: | M.C.T. Truiti, I.C.P. Ferreira, M.L.M. Zamuner, C.V. Nakamura, M.H. Sarragiotto, M.C. Souza |
| المصدر: | Brazilian Journal of Medical and Biological Research, Vol 38, Iss 12, Pp 1873-1878 (2005) |
| بيانات النشر: | Associação Brasileira de Divulgação Científica, 2005. |
| سنة النشر: | 2005 |
| المجموعة: | LCC:Medicine (General) LCC:Biology (General) |
| مصطلحات موضوعية: | Cayaponia podantha, Helicteres gardneriana, Melochia arenosa, Nectandra falcifolia, Paullinia elegans, Antiprotozoal activity, Molluscicidal activity, Medicine (General), R5-920, Biology (General), QH301-705.5 |
| الوصف: | Leishmaniasis, Chagas' disease and schistosomiasis (bilharzia) are parasitic diseases with wide distribution on the American continent, affecting millions of people. In the present study, biological assays for antiprotozoal and molluscicidal activities were carried out with ethanolic extracts of plant species from the Brazilian part of the Upper Paraná River. Crude extracts were obtained by percolation with absolute ethanol from the leaves of Cayaponia podantha Cogn., Nectandra falcifolia (Nees) Castiglioni and Paullinia elegans Cambess., as well as from the aerial parts of Helicteres gardneriana St. Hil. & Naud. and Melochia arenosa Benth., all belonging to genera used in folk medicine. Trypanocidal activity of plants was assayed on epimastigote cultures in liver infusion tryptose. Anti-leishmanial activity was determined over cultures of promastigote forms of the parasite in Schneider's Drosophila medium. Microscopic countings of parasites, after their incubation in the presence of different concentrations of the crude extracts, were made in order to determine the percentage of growth inhibition. C. podantha and M. arenosa, at a concentration of 10 µg/mL, showed 90.4 ± 11.52 and 88.9 ± 2.20% growth inhibition, respectively, of epimastigote forms of Trypanosoma cruzi, whereas N. falcifolia demonstrated an LD50 of 138.5 µg/mL against promastigote forms of Leishmania (Viannia) braziliensis. Regarding molluscicidal activity, the acute toxicity of the extracts on Biomphalaria glabrata was evaluated by a rapid screening procedure. M. arenosa was 100% lethal to snails at 200 µg/mL and showed an LD50 of 143 µg/mL. Screening of plant extracts represents a continuous effort to find new antiparasitic drugs. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 0100-879X 1414-431X |
| Relation: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2005001200016; https://doaj.org/toc/0100-879X; https://doaj.org/toc/1414-431X |
| DOI: | 10.1590/S0100-879X2005001200016 |
| URL الوصول: | https://doaj.org/article/485700d3353d4b7e9ccd7f0fc9984d1e |
| رقم الأكسشن: | edsdoj.485700d3353d4b7e9ccd7f0fc9984d1e |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 0100879X 1414431X |
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| DOI: | 10.1590/S0100-879X2005001200016 |