دورية أكاديمية
أعرض في EDS

Heterogeneity in surface sensing suggests a division of labor in Pseudomonas aeruginosa populations

التفاصيل البيبلوغرافية
العنوان: Heterogeneity in surface sensing suggests a division of labor in Pseudomonas aeruginosa populations
المؤلفون: Catherine R Armbruster, Calvin K Lee, Jessica Parker-Gilham, Jaime de Anda, Aiguo Xia, Kun Zhao, Keiji Murakami, Boo Shan Tseng, Lucas R Hoffman, Fan Jin, Caroline S Harwood, Gerard CL Wong, Matthew R Parsek
المصدر: eLife, Vol 8 (2019)
بيانات النشر: eLife Sciences Publications Ltd, 2019.
سنة النشر: 2019
المجموعة: LCC:Medicine
LCC:Science
LCC:Biology (General)
مصطلحات موضوعية: Pseudomonas aeruginosa, biofilm, c-di-gmp, surface sensing, Wsp system, Medicine, Science, Biology (General), QH301-705.5
الوصف: The second messenger signaling molecule cyclic diguanylate monophosphate (c-di-GMP) drives the transition between planktonic and biofilm growth in many bacterial species. Pseudomonas aeruginosa has two surface sensing systems that produce c-di-GMP in response to surface adherence. Current thinking in the field is that once cells attach to a surface, they uniformly respond by producing c-di-GMP. Here, we describe how the Wsp system generates heterogeneity in surface sensing, resulting in two physiologically distinct subpopulations of cells. One subpopulation has elevated c-di-GMP and produces biofilm matrix, serving as the founders of initial microcolonies. The other subpopulation has low c-di-GMP and engages in surface motility, allowing for exploration of the surface. We also show that this heterogeneity strongly correlates to surface behavior for descendent cells. Together, our results suggest that after surface attachment, P. aeruginosa engages in a division of labor that persists across generations, accelerating early biofilm formation and surface exploration.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2050-084X
Relation: https://elifesciences.org/articles/45084; https://doaj.org/toc/2050-084X
DOI: 10.7554/eLife.45084
URL الوصول: https://doaj.org/article/c486becfeac94d42920e320488c004bc
رقم الأكسشن: edsdoj.486becfeac94d42920e320488c004bc
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:2050084X
DOI:10.7554/eLife.45084