دورية أكاديمية
Integrative study of Arabidopsis thaliana metabolomic and transcriptomic data with the interactive MarVis-Graph software
| العنوان: | Integrative study of Arabidopsis thaliana metabolomic and transcriptomic data with the interactive MarVis-Graph software |
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| المؤلفون: | Manuel Landesfeind, Alexander Kaever, Kirstin Feussner, Corinna Thurow, Christiane Gatz, Ivo Feussner, Peter Meinicke |
| المصدر: | PeerJ, Vol 2, p e239 (2014) |
| بيانات النشر: | PeerJ Inc., 2014. |
| سنة النشر: | 2014 |
| المجموعة: | LCC:Medicine LCC:Biology (General) |
| مصطلحات موضوعية: | Metabolomics, Transcriptomics, Metabolic network analysis, DNA microarray, Metabolite fingerprinting, Medicine, Biology (General), QH301-705.5 |
| الوصف: | State of the art high-throughput technologies allow comprehensive experimental studies of organism metabolism and induce the need for a convenient presentation of large heterogeneous datasets. Especially, the combined analysis and visualization of data from different high-throughput technologies remains a key challenge in bioinformatics. We present here the MarVis-Graph software for integrative analysis of metabolic and transcriptomic data. All experimental data is investigated in terms of the full metabolic network obtained from a reference database. The reactions of the network are scored based on the associated data, and sub-networks, according to connected high-scoring reactions, are identified. Finally, MarVis-Graph scores the detected sub-networks, evaluates them by means of a random permutation test and presents them as a ranked list. Furthermore, MarVis-Graph features an interactive network visualization that provides researchers with a convenient view on the results. The key advantage of MarVis-Graph is the analysis of reactions detached from their pathways so that it is possible to identify new pathways or to connect known pathways by previously unrelated reactions. The MarVis-Graph software is freely available for academic use and can be downloaded at: http://marvis.gobics.de/marvis-graph. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2167-8359 |
| Relation: | https://peerj.com/articles/239.pdf; https://peerj.com/articles/239/; https://doaj.org/toc/2167-8359 |
| DOI: | 10.7717/peerj.239 |
| URL الوصول: | https://doaj.org/article/c4875c4667f847f3a4046cea14295c6d |
| رقم الأكسشن: | edsdoj.4875c4667f847f3a4046cea14295c6d |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 21678359 |
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| DOI: | 10.7717/peerj.239 |