دورية أكاديمية
أعرض في EDS

Combination of Transcriptomics and Proteomics Reveals Differentially Expressed Genes and Proteins in the Skin of EDAR Gene-Targeted and Wildtype Cashmere Goats

التفاصيل البيبلوغرافية
العنوان: Combination of Transcriptomics and Proteomics Reveals Differentially Expressed Genes and Proteins in the Skin of EDAR Gene-Targeted and Wildtype Cashmere Goats
المؤلفون: Gui-Zhen Gao, Fei Hao, Lei Zhu, Guo-Qing Jiang, Wei Yan, Jie Liu, Dong-Jun Liu
المصدر: Animals, Vol 13, Iss 9, p 1452 (2023)
بيانات النشر: MDPI AG, 2023.
سنة النشر: 2023
المجموعة: LCC:Veterinary medicine
LCC:Zoology
مصطلحات موضوعية: EDAR, cashmere goats, hair follicle, transcriptome, proteomics, regulatory network, Veterinary medicine, SF600-1100, Zoology, QL1-991
الوصف: Cashmere goats play a pivotal role in the animal hair industry and are economically valuable. Cashmere is produced through the periodic growth of secondary hair follicles. To improve their yield of cashmere, the regulatory mechanisms of cashmere follicle growth and development need to be analysed. Therefore, in this study, EDAR gene-targeted cashmere goats were used as an animal model to observe the phenotypic characteristics of abnormal hair growth and development at the top of the head. Transcriptomic and proteomic techniques were used to screen for differentially expressed genes and proteins. In total, 732 differentially expressed genes were identified, including 395 upregulated and 337 downregulated genes. In addition, 140 differentially expressed proteins were identified, including 69 upregulated and 71 downregulated proteins. These results provide a research target for elucidating the mechanism through which EDAR regulates hair follicle growth in cashmere goats. It also enriches the available data on the regulatory network involved in hair follicle growth.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2076-2615
Relation: https://www.mdpi.com/2076-2615/13/9/1452; https://doaj.org/toc/2076-2615
DOI: 10.3390/ani13091452
URL الوصول: https://doaj.org/article/e48b937f595747809c91cd076dcd5d95
رقم الأكسشن: edsdoj.48b937f595747809c91cd076dcd5d95
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:20762615
DOI:10.3390/ani13091452