Linear ubiquitination is involved in the pathogenesis of optineurin-associated amyotrophic lateral sclerosis

التفاصيل البيبلوغرافية
العنوان:	Linear ubiquitination is involved in the pathogenesis of optineurin-associated amyotrophic lateral sclerosis
المؤلفون:	Seshiru Nakazawa, Daisuke Oikawa, Ryohei Ishii, Takashi Ayaki, Hirotaka Takahashi, Hiroyuki Takeda, Ryuichiro Ishitani, Kiyoko Kamei, Izumi Takeyoshi, Hideshi Kawakami, Kazuhiro Iwai, Izuho Hatada, Tatsuya Sawasaki, Hidefumi Ito, Osamu Nureki, Fuminori Tokunaga
المصدر:	Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
بيانات النشر:	Nature Portfolio, 2016.
سنة النشر:	2016
المجموعة:	LCC:Science
مصطلحات موضوعية:	Science
الوصف:	Mutations in optineurin are associated with neurodegenerative diseases, including amyotrophic lateral sclerosis. Here, the authors report the structure of the ubiquitin binding domain of optineurin, which binds linear ubiquitin with homology to NEMO, and explore the function of this domain.
نوع الوثيقة:	article
وصف الملف:	electronic resource
اللغة:	English
تدمد:	2041-1723
Relation:	https://doaj.org/toc/2041-1723
DOI:	10.1038/ncomms12547
URL الوصول:	https://doaj.org/article/48d2514f3f7d45fdab8f96492f0c4c45
رقم الأكسشن:	edsdoj.48d2514f3f7d45fdab8f96492f0c4c45
قاعدة البيانات:	Directory of Open Access Journals

الوصف
تدمد:	20411723
DOI:	10.1038/ncomms12547