دورية أكاديمية
Assessment of cardiometabolic risk factors in various phenotypes of masked hypertension
| العنوان: | Assessment of cardiometabolic risk factors in various phenotypes of masked hypertension |
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| المؤلفون: | B. I. Geltser, V. V. Orlova-Ilinskaya, O. O. Vetrova, V. N. Kotelnikov, R. S. Karpov |
| المصدر: | Кардиоваскулярная терапия и профилактика, Vol 19, Iss 4 (2020) |
| بيانات النشر: | «SILICEA-POLIGRAF» LLC, 2020. |
| سنة النشر: | 2020 |
| المجموعة: | LCC:Diseases of the circulatory (Cardiovascular) system |
| مصطلحات موضوعية: | маскированная артериальная гипертензия, факторы риска, кластерный анализ, Diseases of the circulatory (Cardiovascular) system, RC666-701 |
| الوصف: | Aim. To assess the relationship of cardiometabolic risk factors in patients with various phenotypes of masked hypertension (MH).Material and methods. The study included 207 men with a median age of 34,6 years [32,3; 36,3] being systematically stressed. All examined patients had normal clinical blood pressure (BP), and there was no history of its increase. We conducted 24-hour ambulatory blood pressure monitoring (ABPM), carotid duplex scan with determination of the intima- media thickness (IMT). The levels of total cholesterol (TC), low (LDLC) and high-density lipoprotein cholesterol (HDL-C), triglycerides (TG) were determined. Body mass index, visceral adiposity index, lipid accumulation product index and waist-to-height ratio were calculated. We performed clustering of ABPM data, calculated the odds ratio of association between cardiometabolic risk factors and certain MH phenotypes.Results. MH was diagnosed in 142 (68,6%) patients examined, divided into 3 clusters: systolic-diastolic — SDMH (50,7%), isolated systolic — ISMH (27,5%) and isolated diastolic — IDMH (21,8%). Impaired lipid metabolism, visceral adiposity, IMT increase and atherosclerotic plaques were more often recorded in patients with SDMH and IDMH. The levels of TC, LDL-C and IMT were highest in individuals with IDMH. Odds ratio analysis indicated significant associations of SDMH and IDMH phenotypes with indicators of visceral adiposity, IMT, TG, TC, LDL-C and TG/HDL-Cl.Conclusion. Clustering of ABPM data in individuals with MH and comparing related phenotypes with cardiometabolic risk factors complements their clinical and functional characteristics and can be a useful tool for improving customized prevention and therapy programs. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | Russian |
| تدمد: | 1728-8800 2619-0125 |
| Relation: | https://cardiovascular.elpub.ru/jour/article/view/2422; https://doaj.org/toc/1728-8800; https://doaj.org/toc/2619-0125 |
| DOI: | 10.15829/1728-8800-2020-2422 |
| URL الوصول: | https://doaj.org/article/c48dce232cb1475d8e4b20d1c3d25bbb |
| رقم الأكسشن: | edsdoj.48dce232cb1475d8e4b20d1c3d25bbb |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 17288800 26190125 |
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| DOI: | 10.15829/1728-8800-2020-2422 |